An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin

by Joshua R. Burns, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Published 2019-07-01

Drugging the Undruggable: Inhibiting MYCN Signalling

by Jessica K. Holien, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Published 2019-10-01

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

by Harmeet Singh, Tracy L Nero, Yao Wang, Michael W Parker, Guiying Nie
Published 2014-01-01

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407

by Carla Hodson, Ji Yang, Dianna M. Hocking, Kristy Azzopardi, Kristy Azzopardi, Qianyu Chen, Jessica K. Holien, Michael W. Parker, Michael W. Parker, Marija Tauschek, Roy M. Robins-Browne, Roy M. Robins-Browne
Published 2017-08-01

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins.

by Maryam Molakarimi, Ammar Mohseni, Majid Taghdir, Zaiddodine Pashandi, Michael A Gorman, Michael W Parker, Hossein Naderi-Manesh, Reza H Sajedi
Published 2017-01-01

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation.

by Huiting Ho, Harmeet Singh, Sophea Heng, Tracy L Nero, Sarah Paule, Michael W Parker, Alan T Johnson, Guan-Sheng Jiao, Guiying Nie
Published 2013-01-01

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.

by Jessica L Bell, Alena Malyukova, Jessica K Holien, Jessica Koach, Michael W Parker, Maria Kavallaris, Glenn M Marshall, Belamy B Cheung
Published 2012-01-01

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

by Winnie Tan, Sylvie van Twest, Andrew Leis, Rohan Bythell-Douglas, Vincent J Murphy, Michael Sharp, Michael W Parker, Wayne Crismani, Andrew J Deans
Published 2020-03-01

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin.

by Winnie Tan, Vincent J Murphy, Aude Charron, Sylvie van Twest, Michael Sharp, Angelos Constantinou, Michael W Parker, Wayne Crismani, Rohan Bythell-Douglas, Andrew J Deans
Published 2020-01-01

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

by Chantal L Márquez, Derrick Lau, James Walsh, Vaibhav Shah, Conall McGuinness, Andrew Wong, Anupriya Aggarwal, Michael W Parker, David A Jacques, Stuart Turville, Till Böcking
Published 2018-06-01

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

by Christopher G. Langendorf, Kevin R. W. Ngoei, John W. Scott, Naomi X. Y. Ling, Sam M. A. Issa, Michael A. Gorman, Michael W. Parker, Kei Sakamoto, Jonathan S. Oakhill, Bruce E. Kemp
Published 2016-03-01

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

by Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Published 2019-04-01

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

by Zsuzsanna Nagy, Janith A. Seneviratne, Maxwell Kanikevich, William Chang, Chelsea Mayoh, Pooja Venkat, Yanhua Du, Cizhong Jiang, Alice Salib, Jessica Koach, Daniel R. Carter, Rituparna Mittra, Tao Liu, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Published 2021-03-01

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

by Alexandr N Simonov, Jessica K Holien, Joyee Chun In Yeung, Ann D Nguyen, C Jo Corbin, Jie Zheng, Vladimir L Kuznetsov, Richard J Auchus, Alan J Conley, Alan M Bond, Michael W Parker, Raymond J Rodgers, Lisandra L Martin
Published 2015-01-01

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

by Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Published 2019-09-01

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

by Con Dogovski, Michael A Gorman, Natalia E Ketaren, Judy Praszkier, Leanne M Zammit, Haydyn D Mertens, Gary Bryant, Ji Yang, Michael D W Griffin, F Grant Pearce, Juliet A Gerrard, Geoffrey B Jameson, Michael W Parker, Roy M Robins-Browne, Matthew A Perugini
Published 2013-01-01

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

by Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker
Published 2018-01-01

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

by Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Published 2019-04-01

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

by David Braig, Tracy L. Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R. Thiele, Craig J. Morton, Johannes Zeller, Jurij Kiefer, Lawrence A. Potempa, Natalie A. Mellett, Luke A. Miles, Xiao-Jun Du, Peter J. Meikle, Markus Huber-Lang, G. Björn Stark, Michael W. Parker, Karlheinz Peter, Steffen U. Eisenhardt
Published 2017-01-01

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

by Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez
Published 2014-07-01