In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide

by Connie Le, Reshma Sirajee, Rineke Steenbergen, Michael A. Joyce, William R. Addison, D. Lorne Tyrrell
Published 2021-01-01

HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response.

by Michael A Joyce, Karyn M Berry-Wynne, Theodore Dos Santos, William R Addison, Nicola McFarlane, Tom Hobman, D Lorne Tyrrell
Published 2019-08-01

Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication.

by Christopher J Neufeldt, Michael A Joyce, Aviad Levin, Rineke H Steenbergen, Daniel Pang, Justin Shields, D Lorne J Tyrrell, Richard W Wozniak
Published 2013-10-01

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.

by Christopher J Neufeldt, Michael A Joyce, Nicholas Van Buuren, Aviad Levin, Karla Kirkegaard, Michael Gale, D Lorne J Tyrrell, Richard W Wozniak
Published 2016-02-01

Functional characterization of nuclear localization and export signals in hepatitis C virus proteins and their role in the membranous web.

by Aviad Levin, Christopher J Neufeldt, Daniel Pang, Kristen Wilson, Darci Loewen-Dobler, Michael A Joyce, Richard W Wozniak, D Lorne J Tyrrell
Published 2014-01-01

HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice.

by Michael A Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S Doyle, Michael G Katze, D Lorne Tyrrell
Published 2009-02-01

Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response.

by Kathie-Anne Walters, Michael A Joyce, Jill C Thompson, Maria W Smith, Matthew M Yeh, Sean Proll, Lin-Fu Zhu, T J Gao, Norman M Kneteman, D Lorne Tyrrell, Michael G Katze
Published 2006-06-01

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

by Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Published 2020-10-01

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

by Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Published 2020-08-01

IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.

by Adrian Egli, Deanna M Santer, Daire O'Shea, Khaled Barakat, Mohammedyaseen Syedbasha, Madeleine Vollmer, Aliyah Baluch, Rakesh Bhat, Jody Groenendyk, Michael A Joyce, Luiz F Lisboa, Brad S Thomas, Manuel Battegay, Nina Khanna, Thomas Mueller, D Lorne J Tyrrell, Michael Houghton, Atul Humar, Deepali Kumar
Published 2014-12-01

Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2

by Manisha Pandey, Victoria Ozberk, Sharareh Eskandari, Ahmed O Shalash, Michael A Joyce, Holly A Saffran, Christopher J Day, Ailin Lepletier, Belinda L Spillings, Jamie‐Lee Mills, Ainslie Calcutt, Fan Fan, James T Williams, Danielle I Stanisic, Laetitia Hattingh, John Gerrard, Mariusz Skwarczynski, Johnson Mak, Michael P Jennings, Istvan Toth, D Lorne Tyrrell, Michael F Good
Published 2021-01-01