Therapeutic potential of the translation inhibitor silvestrol in hepatocellular cancer.

by Takayuki Kogure, A Douglas Kinghorn, Irene Yan, Brad Bolon, David M Lucas, Michael R Grever, Tushar Patel
Published 2013-01-01

PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).

by Courtney Nicholas, Jennifer Yang, Sara B Peters, Matthew A Bill, Robert A Baiocchi, Fengting Yan, Saïd Sïf, Sookil Tae, Eugenio Gaudio, Xin Wu, Michael R Grever, Gregory S Young, Gregory B Lesinski
Published 2013-01-01

Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.

by Jianhua Yu, Yong Peng, Lai-Chu Wu, Zhiliang Xie, Youcai Deng, Tiffany Hughes, Shun He, XiaoKui Mo, Ming Chiu, Qi-En Wang, Xiaoming He, Shujun Liu, Michael R Grever, Kenneth K Chan, Zhongfa Liu
Published 2013-01-01

Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.

by Wenjun Ni, Jia Ji, Zunyan Dai, Audrey Papp, Amy J Johnson, Sunjoo Ahn, Katherine L Farley, Thomas S Lin, James T Dalton, Xiaobai Li, David Jarjoura, John C Byrd, Wolfgang Sadee, Michael R Grever, Mitch A Phelps
Published 2010-11-01

The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.

by David M Lucas, Lapo Alinari, Derek A West, Melanie E Davis, Ryan B Edwards, Amy J Johnson, Kristie A Blum, Craig C Hofmeister, Michael A Freitas, Mark R Parthun, Dasheng Wang, Amy Lehman, Xiaoli Zhang, David Jarjoura, Samuel K Kulp, Carlo M Croce, Michael R Grever, Ching-Shih Chen, Robert A Baiocchi, John C Byrd
Published 2010-06-01