Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.

by Geneviève Doyon, Michele D Sobolewski, Kelly Huber, Deborah McMahon, John W Mellors, Nicolas Sluis-Cremer
Published 2014-01-01

Comparison of methods to quantify inducible HIV-1 outgrowth

by P. Nathan Enick, Joseph P. Brooker, Camille M. Tumiotto, Brittany T. Staines, Joseph J. Eron, Deborah K. McMahon, Rajesh T. Gandhi, John W. Mellors, Michele D. Sobolewski
Published 2021-06-01

Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells.

by John K Bui, Elias K Halvas, Elizabeth Fyne, Michele D Sobolewski, Dianna Koontz, Wei Shao, Brian Luke, Feiyu F Hong, Mary F Kearney, John W Mellors
Published 2017-02-01

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir.

by John K Bui, Michele D Sobolewski, Brandon F Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T Luke, Wei Shao, Stephen H Hughes, John M Coffin, Mary F Kearney, John W Mellors
Published 2017-03-01

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy.

by John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes
Published 2021-04-01

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

by Andrew Musick, Jonathan Spindler, Eli Boritz, Liliana Pérez, Daniel Crespo-Vélez, Sean C. Patro, Michele D. Sobolewski, Michael J. Bale, Carolyn Reid, Brandon F. Keele, Adam Capoferri, Wei Shao, Ann Wiegand, Francesco R. Simonetti, John W. Mellors, Stephen H. Hughes, John M. Coffin, Frank Maldarelli, Mary F. Kearney
Published 2019-10-01

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size.

by Daniel I S Rosenbloom, Peter Bacchetti, Mars Stone, Xutao Deng, Ronald J Bosch, Douglas D Richman, Janet D Siliciano, John W Mellors, Steven G Deeks, Roger G Ptak, Rebecca Hoh, Sheila M Keating, Melanie Dimapasoc, Marta Massanella, Jun Lai, Michele D Sobolewski, Deanna A Kulpa, Michael P Busch, Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Published 2019-04-01