Dealing with the challenge of building a Biochemistry Program in an integrated Medical curriculum. The need for new didactics, new focal interests, and new connections to other dis...

by Miguel A. R. B. Castanho
Published 2017-07-01

The mechanism of action of antimicrobial peptides: lipid vesicles vs. bacteria.

by Manuel N. Melo, Miguel A. R. B. Castanho
Published 2012-08-01

Lipossomas: a bala mágica acertou? Liposomes: has the magic bullet hit the target?

by Nuno C. Santos, Miguel A. R. B. Castanho
Published 2002-12-01

HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes.

by Pedro M Matos, Miguel A R B Castanho, Nuno C Santos
Published 2010-01-01

rBPI(21) promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes.

by Marco M Domingues, Miguel A R B Castanho, Nuno C Santos
Published 2009-12-01

Editorial: Bridging Membrane Biophysics to Microbiology: Innovating Towards New Peptide and Peptide-Based Antimicrobials

by Lorenzo Stella, Sergey A. Akimov, Sattar Taheri-Araghi, Miguel A. R. B. Castanho
Published 2021-07-01

Estimating peptide half‐life in serum from tunable, sequence‐related physicochemical properties

by Marco Cavaco, Javier Valle, Isabel Flores, David Andreu, Miguel A. R. B. Castanho
Published 2021-07-01

Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-membrane interactions potentiating its action.

by Axel Hollmann, Pedro M Matos, Marcelo T Augusto, Miguel A R B Castanho, Nuno C Santos
Published 2013-01-01

Prediction of antibacterial activity from physicochemical properties of antimicrobial peptides.

by Manuel N Melo, Rafael Ferre, Lídia Feliu, Eduard Bardají, Marta Planas, Miguel A R B Castanho
Published 2011-01-01

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model

by Sara Neves-Coelho, Rute P. Eleutério, Francisco J. Enguita, Vera Neves, Miguel A. R. B. Castanho
Published 2017-10-01

Neuropeptide Kyotorphin (Tyrosil-Arginine) has decreased levels in the cerebrospinal fluid of Alzheimer’s disease patients: Potential diagnostic and pharmacological implications

by Sara Matos Santos, Laura eGarcia-Nimo, Sónia Sá Santos, Isaura eTavares, José A. Cocho, Miguel A. R. B. Castanho
Published 2013-10-01

Overlapping Properties of the Short Membrane-Active Peptide BP100 With (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides

by Christian Mink, Erik Strandberg, Parvesh Wadhwani, Manuel N. Melo, Johannes Reichert, Irene Wacker, Miguel A. R. B. Castanho, Anne S. Ulrich, Anne S. Ulrich
Published 2021-04-01

To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models

by Marco Cavaco, Marco Cavaco, Clara Pérez-Peinado, Javier Valle, Rúben D. M. Silva, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Published 2020-09-01

Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein.

by João Miguel Freire, Ana Salomé Veiga, Thaís M Conceição, Wioleta Kowalczyk, Ronaldo Mohana-Borges, David Andreu, Nuno C Santos, Andrea T Da Poian, Miguel A R B Castanho
Published 2013-01-01

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

by Susana A. Dias, João M. Freire, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga
Published 2017-05-01

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

by Rita F. Belo, Rita F. Belo, Margarida L. F. Martins, Margarida L. F. Martins, Liana Shvachiy, Tiago Costa-Coelho, Tiago Costa-Coelho, Carolina de Almeida-Borlido, Carolina de Almeida-Borlido, João Fonseca-Gomes, João Fonseca-Gomes, Vera Neves, Vera Neves, Hugo Vicente Miranda, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Joana E. Coelho, Sara Xapelli, Sara Xapelli, Cláudia A. Valente, Cláudia A. Valente, Montserrat Heras, Eduard Bardaji, Miguel A. R. B. Castanho, Miguel A. R. B. Castanho, Maria José Diógenes, Maria José Diógenes, Ana M. Sebastião, Ana M. Sebastião
Published 2020-07-01

A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography

by David Cordeiro Sousa, David Cordeiro Sousa, David Cordeiro Sousa, Inês Leal, Inês Leal, Susana Moreira, Sónia do Vale, Sónia do Vale, Ana S. Silva-Herdade, Patrício Aguiar, Patrício Aguiar, Patrícia Dionísio, Luís Abegão Pinto, Luís Abegão Pinto, Miguel A. R. B. Castanho, Carlos Marques-Neves, Carlos Marques-Neves
Published 2019-06-01

Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System

by Miguel de Almeida Fuzeta, Miguel de Almeida Fuzeta, Nuno Bernardes, Filipa D. Oliveira, Ana Catarina Costa, Ana Fernandes-Platzgummer, José Paulo Farinha, Carlos A. V. Rodrigues, Sunghoon Jung, Rong-Jeng Tseng, William Milligan, Brian Lee, Miguel A. R. B. Castanho, Diana Gaspar, Joaquim M. S. Cabral, Cláudia Lobato da Silva
Published 2020-11-01

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.

by Frederic Vigant, Jihye Lee, Axel Hollmann, Lukas B Tanner, Zeynep Akyol Ataman, Tatyana Yun, Guanghou Shui, Hector C Aguilar, Dong Zhang, David Meriwether, Gleyder Roman-Sosa, Lindsey R Robinson, Terry L Juelich, Hubert Buczkowski, Sunwen Chou, Miguel A R B Castanho, Mike C Wolf, Jennifer K Smith, Ashley Banyard, Margaret Kielian, Srinivasa Reddy, Markus R Wenk, Matthias Selke, Nuno C Santos, Alexander N Freiberg, Michael E Jung, Benhur Lee
Published 2013-01-01