Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

by Marie S Hasemann, Mikkel B Schuster, Anne-Katrine Frank, Kim Theilgaard-Mönch, Thomas Å Pedersen, Claus Nerlov, Bo T Porse
Published 2012-01-01

C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.

by Marie S Hasemann, Felicia K B Lauridsen, Johannes Waage, Janus S Jakobsen, Anne-Katrine Frank, Mikkel B Schuster, Nicolas Rapin, Frederik O Bagger, Philipp S Hoppe, Timm Schroeder, Bo T Porse
Published 2014-01-01