Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

by Laila Silamiķele, Ivars Silamiķelis, Monta Ustinova, Zane Kalniņa, Ilze Elbere, Ramona Petrovska, Ineta Kalniņa, Jānis Kloviņš
Published 2021-03-01

Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

by Monta Ustinova, Raitis Peculis, Raimonds Rescenko, Vita Rovite, Linda Zaharenko, Ilze Elbere, Laila Silamikele, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Published 2021-01-01

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response.

by Monta Ustinova, Laura Ansone, Ivars Silamikelis, Vita Rovite, Ilze Elbere, Laila Silamikele, Ineta Kalnina, Davids Fridmanis, Jelizaveta Sokolovska, Ilze Konrade, Valdis Pirags, Janis Klovins
Published 2020-01-01

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.

by Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Published 2019-01-01

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients.

by Ilze Elbere, Ivars Silamikelis, Ilze Izabella Dindune, Ineta Kalnina, Monta Ustinova, Linda Zaharenko, Laila Silamikele, Vita Rovite, Dita Gudra, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Published 2020-01-01

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

by Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Published 2018-12-01

First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

by Nikita Zrelovs, Monta Ustinova, Ivars Silamikelis, Liga Birzniece, Kaspars Megnis, Vita Rovite, Lauma Freimane, Laila Silamikele, Laura Ansone, Janis Pjalkovskis, Davids Fridmanis, Baiba Vilne, Marta Priedite, Anastasija Caica, Mikus Gavars, Dmitry Perminov, Dmitry Perminov, Jelena Storozenko, Jelena Storozenko, Oksana Savicka, Oksana Savicka, Elina Dimina, Uga Dumpis, Uga Dumpis, Janis Klovins
Published 2021-04-01