Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

by Muir, Alexander, Danai, Laura V., Vander Heiden, Matthew G.
Published 2019

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

by Lewis, Caroline A, Muir, Alexander, Danai, Laura V, Gui, Dan Yi, Waingarten, Chiara Y., Vander Heiden, Matthew G.
Published 2018

Altered exocrine function can drive adipose wasting in early pancreatic cancer

by Danai, Laura V., Dennstedt, Emily A., Muir, Alexander, Lien, Evan C., Mayers, Jared R., Lau, Allison N., Jones-Sali, Paul, Vander Heiden, Matthew G.
Published 2020

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

by Sullivan, Mark Robert, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Yi, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G., Muir, Alexander
Published 2021

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

by Sullivan, Mark Robert, Mattaini, Katherine Ruth, Dennstedt, Emily A, Nguyen, Anna, Sivanand, Sharanya, Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia, Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

by Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Papagiannakopoulos, Thales, Davidson, Shawn M, Muir, Alexander, Vander Heiden, Matthew G.
Published 2018

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

by Ji, B. W., Dixit, P. D., Wolpin, B. M., Vitkup, D., Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Hosios, Aaron Marc, Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2018

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1

by Romero, Rodrigo, Sánchez-Rivera, Francisco J, Westcott, Peter MK, Mercer, Kim L, Bhutkar, Arjun, Muir, Alexander, González Robles, Tania J, Lamboy Rodríguez, Swanny, Liao, Laura Z, Ng, Sheng Rong, Li, Leanne, Colón, Caterina I, Naranjo, Santiago, Beytagh, Mary Clare, Lewis, Caroline A, Hsu, Peggy P, Bronson, Roderick T, Vander Heiden, Matthew G, Jacks, Tyler
Published 2021