A Critical Role of Zinc Importer AdcABC in Group A Streptococcus-Host Interactions During Infection and Its Implications for Vaccine Development

by Nishanth Makthal, Kimberly Nguyen, Hackwon Do, Maire Gavagan, Pete Chandrangsu, John D. Helmann, Randall J. Olsen, Muthiah Kumaraswami
Published 2017-07-01

Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway

by Hackwon Do, Nishanth Makthal, Arica R. VanderWal, Matthew Ojeda Saavedra, Randall J. Olsen, James M. Musser, Muthiah Kumaraswami
Published 2019-06-01

Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus.

by Nicola Horstmann, Chau Nguyen Tran, Chelcy Brumlow, Sruti DebRoy, Hui Yao, Graciela Nogueras Gonzalez, Nishanth Makthal, Muthiah Kumaraswami, Samuel A Shelburne
Published 2018-10-01

Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.

by Nicola Horstmann, Pranoti Sahasrabhojane, Bryce Suber, Muthiah Kumaraswami, Randall J Olsen, Anthony Flores, James M Musser, Richard G Brennan, Samuel A Shelburne
Published 2011-10-01