Nabil Seidah
Nabil G. Seidah, (born 1949) is a Canadian Québécois scientist. Born in Egypt, he was educated at Cairo University, and subsequently at Georgetown University where he obtained his Ph.D. in 1973. He emigrated to Canada and has been working at the Clinical Research Institute of Montreal (IRCM) since 1974. He is the director of the laboratory of Biochemical Neuroendocrinology. He discovered and cloned seven (PC1, PC2, PC4, PC5, PC7, SKI-1 and PCSK9) of the nine known enzymes belonging to the convertase family. During this period, he also greatly contributed to demonstrating that the proteolysis by the proprotein convertases is a wide mechanism that also concerns “non-neuropeptide” proteins such as growth factors, α-integrins, receptors, enzymes, membrane-bound transcription factors, and bacterial and viral proteins. In 2003, he discovered PCSK9 and showed that point mutations in the PCSK9 gene cause dominant familial hypercholesterolemia, likely because of a gain of function related to the ability of PCSK9 to enhance the degradation of cell surface receptors, such as the low-density lipoprotein receptor (LDLR). He has since worked on the elucidation of the functions and mechanisms of action of PCSK9 and PCSK7 both in cells and in vivo, and is developing specific PCSK9 and PCSK7 inhibitors/silencers. Provided by Wikipedia-
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5by Parisa Naeli, Fatemeh Mirzadeh Azad, Mahshid Malakootian, Nabil G. Seidah, Seyed J. MowlaGet full text
Published 2017-11-01
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6by Sitaram Harihar, Keke M Pounds, Tomoo Iwakuma, Nabil G Seidah, Danny R WelchGet full text
Published 2014-01-01
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7by Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G. Seidah, Shoumo BhattacharyaGet full text
Published 2017-04-01
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10by Artuela Çaku, Nabil G Seidah, Audrey Lortie, Nancy Gagné, Patrice Perron, Jean Dubé, Francois CorbinGet full text
Published 2017-01-01
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13by Alain Le Coupanec, Marc Desforges, Mathieu Meessen-Pinard, Mathieu Dubé, Robert Day, Nabil G Seidah, Pierre J TalbotGet full text
Published 2015-01-01
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14by Deborah Maret, Mohamad Seyed Sadr, Emad Seyed Sadr, David R Colman, Rolando F Del Maestro, Nabil G SeidahGet full text
Published 2012-10-01
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17by Rocco Romagnuolo, Corey A Scipione, Santica M Marcovina, Matthew Gemin, Nabil G Seidah, Michael B Boffa, Marlys L KoschinskyGet full text
Published 2017-01-01
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18by Bin Dong, Minhao Wu, Hai Li, Fredric B. Kraemer, Khosrow Adeli, Nabil G. Seidah, Sahng Wook Park, Jingwen LiuGet full text
Published 2010-06-01
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20by Nidhi Gupta, Niels Fisker, Marie-Claude Asselin, Marie Lindholm, Christoph Rosenbohm, Henrik Ørum, Joacim Elmén, Nabil G Seidah, Ellen Marie StraarupGet full text
Published 2010-05-01
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