Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

by Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran
Published 2017-05-01

Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological Remodeling

by Gobinath Shanmugam, Anil K. Challa, Asokan Devarajan, Baskaran Athmanathan, Silvio H. Litovsky, Prasanna Krishnamurthy, Christopher J. Davidson, Namakkal Soorappan Rajasekaran, Namakkal Soorappan Rajasekaran, Namakkal Soorappan Rajasekaran
Published 2019-06-01

Redox Signaling and the Cardiovascular and Skeletal Muscle System

by Aldrin V. Gomes, Namakkal S. Rajasekaran, Xinchun Pi
Published 2015-01-01

Reductive stress impairs myogenic differentiation

by Namakkal S. Rajasekaran, Sandeep Balu Shelar, Dean P. Jones, John R. Hoidal
Published 2020-07-01

Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium

by Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, Namakkal S. Rajasekaran
Published 2017-08-01

Identification of transcriptome signature for myocardial reductive stress

by Justin M. Quiles, Madhusudhanan Narasimhan, Timothy Mosbruger, Gobinath Shanmugam, David Crossman, Namakkal S. Rajasekaran
Published 2017-10-01

Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

by Justin M. Quiles, Madhusudhanan Narasimhan, Gobinath Shanmugam, Brett Milash, John R. Hoidal, Namakkal S. Rajasekaran
Published 2017-07-01

Reductive stress promotes protein aggregation and impairs neurogenesis

by Kishore Kumar S Narasimhan, Asokan Devarajan, Goutam Karan, Sandhya Sundaram, Qin Wang, Thomas van Groen, Federica del Monte, Namakkal S. Rajasekaran
Published 2020-10-01

Evidence for a hyper-reductive redox in a sub-set of heart failure patients

by Thiagarajan Sairam, Amit N. Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M. Pogwizd, Sudha Ramalingam, Ramalingam Sankaran, Namakkal Soorapan Rajasekaran
Published 2018-05-01

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

by Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
Published 2019-10-01

Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1/Nrf2/ARE Signaling Pathway

by Kishore Kumar S. Narasimhan, Deepthy Jayakumar, Prema Velusamy, Ashokkumar Srinivasan, Thangarajeswari Mohan, Divya Bhavani Ravi, Saraswathi Uthamaraman, Yogesh Kanna Sathyamoorthy, Namakkal Soorappan Rajasekaran, Kalaiselvi Periandavan
Published 2019-01-01

The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster.

by Heng B Xie, Anthony Cammarato, Namakkal S Rajasekaran, Huali Zhang, Jennifer A Suggs, Ho-Chen Lin, Sanford I Bernstein, Ivor J Benjamin, Kent G Golic
Published 2013-06-01

A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes

by Gobinath Shanmugam, Madhusudhanan Narasimhan, Ramasamy Sakthivel, Rajesh Kumar R, Christopher Davidson, Sethu Palaniappan, William W. Claycomb, John R. Hoidal, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
Published 2016-10-01

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

by Sellamuthu S. Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J. Miller, Kevin S. Whitehead, Shannon J. Odelberg, Matthew A. Firpo, Robert Paine, John R. Hoidal, E. Dale Abel, Namakkal S. Rajasekaran
Published 2013-01-01

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training.

by Sellamuthu S. Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J. Miller, Kevin S. Whitehead, Shannon J. Odelberg, Matthew A. Firpo, Robert Paine, John R. Hoidal, E. Dale Abel, Namakkal S. Rajasekaran
Published 2013-01-01

Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress

by Justin M. Quiles, Mark E. Pepin, Sini Sunny, Sandeep B. Shelar, Anil K. Challa, Brian Dalley, John R. Hoidal, Steven M. Pogwizd, Adam R. Wende, Namakkal S. Rajasekaran
Published 2021-06-01

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

by Sellamuthu S. Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J. Miller, Kevin J. Whitehead, Shannon J. Odelberg, Matthew A. Firpo, Robert Paine, John R. Hoidal, E. Dale Abel, Namakkal S. Rajasekaran
Published 2012-01-01

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training.

by Sellamuthu S. Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J. Miller, Kevin J. Whitehead, Shannon J. Odelberg, Matthew A. Firpo, Robert Paine, John R. Hoidal, E. Dale Abel, Namakkal S. Rajasekaran
Published 2012-01-01

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

by Sellamuthu S Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J Miller, Kevin J Whitehead, Shannon J Odelberg, Matthew A Firpo, Robert Paine, John R Hoidal, E Dale Abel, Namakkal S Rajasekaran
Published 2012-01-01

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice

by Kah Yong Goh, Li He, Jiajia Song, Miki Jinno, Aaron J. Rogers, Palaniappan Sethu, Ganesh V. Halade, Namakkal Soorappan Rajasekaran, Xiaoguang Liu, Sumanth D. Prabhu, Victor Darley-Usmar, Adam R. Wende, Lufang Zhou
Published 2019-02-01