TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion.

by Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Published 2012-01-01

TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.

by Falguni Das, Amit Bera, Nandini Ghosh-Choudhury, Hanna E Abboud, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Published 2014-01-01

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression.

by Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Published 2018-01-01

microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion.

by Nirmalya Dey, Falguni Das, Nandini Ghosh-Choudhury, Chandi Charan Mandal, Dipen J Parekh, Karen Block, Balakuntalam S Kasinath, Hanna E Abboud, Goutam Ghosh Choudhury
Published 2012-01-01