Napoleone Ferrara

Napoleone Ferrara (born 26 July 1956 in Catania) is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy. At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available angiogenesis inhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers. Ferrara's work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders. Provided by Wikipedia
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  1. 1
    Iron Metabolism in the Tumor Microenvironment: Contributions of Innate Immune Cells
    by Wei Liang, Napoleone Ferrara
    Published 2021-02-01
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  2. 2
    Endothelial cells regulate neural crest and second heart field morphogenesis
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  3. 3
    Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature.
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  4. 4
    Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways
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  5. 5
    Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells.
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  6. 6
    Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice.
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  7. 7
    Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
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  8. 8
    Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response
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  9. 9
    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
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