Adult Article Female Heterozygote High-Throughput Nucleotide Sequencing Humans Iran Iranian people MITF gene MITF protein, human Male Microphthalmia-Associated Transcription Factor Middle Aged Mutation Pedigree Phenotype Prognosis Sanger sequencing WES Waardenburg Syndrome Waardenburg syndrome Young Adult adult autosomal dominant disorder bilateral hearing loss case report clinical article congenital deafness exon female