Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism

by Natalia Fernández-Borges, Hasier Eraña, Saioa R. Elezgarai, Chafik Harrathi, Mayela Gayosso, Joaquín Castilla
Published 2013-01-01

Detection of PrPres in genetically susceptible fetuses from sheep with natural scrapie.

by María Carmen Garza, Natalia Fernández-Borges, Rosa Bolea, Juan José Badiola, Joaquín Castilla, Eva Monleón
Published 2011-01-01

Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease

by Alicia Otero, Marina Betancor, Hasier Eraña, Natalia Fernández Borges, José J. Lucas, Juan José Badiola, Joaquín Castilla, Rosa Bolea
Published 2021-01-01

Canine D163-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context

by Alba Marín-Moreno, Juan Carlos Espinosa, Patricia Aguilar-Calvo, Natalia Fernández-Borges, José Luis Pitarch, Lorenzo González, Juan María Torres
Published 2021-07-01

Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology.

by Gian Mario Cosseddu, Romolo Nonno, Gabriele Vaccari, Cecilia Bucalossi, Natalia Fernandez-Borges, Michele Angelo Di Bari, Joaquin Castilla, Umberto Agrimi
Published 2011-11-01

Protective Effect of Val129-PrP against Bovine Spongiform Encephalopathy but not Variant Creutzfeldt-Jakob Disease

by Natalia Fernández-Borges, Juan Carlos Espinosa, Alba Marín-Moreno, Patricia Aguilar-Calvo, Emmanuel A. Asante, Tetsuyuki Kitamoto, Shirou Mohri, Olivier Andréoletti, Juan María Torres
Published 2017-09-01

Unraveling the key to the resistance of canids to prion diseases.

by Natalia Fernández-Borges, Beatriz Parra, Enric Vidal, Hasier Eraña, Manuel A Sánchez-Martín, Jorge de Castro, Saioa R Elezgarai, Martí Pumarola, Tomás Mayoral, Joaquín Castilla
Published 2017-11-01

Classical scrapie in small ruminants is caused by at least four different prion strains

by Alba Marín-Moreno, Patricia Aguilar-Calvo, Juan Carlos Espinosa, María Zamora-Ceballos, José Luis Pitarch, Lorenzo González, Natalia Fernández-Borges, Leonor Orge, Olivier Andréoletti, Romolo Nonno, Juan María Torres
Published 2021-04-01

Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates.

by Enric Vidal, Natalia Fernández-Borges, Belén Pintado, Hasier Eraña, Montserrat Ordóñez, Mercedes Márquez, Francesca Chianini, Dolors Fondevila, Manuel A Sánchez-Martín, Olivier Andreoletti, Mark P Dagleish, Martí Pumarola, Joaquín Castilla
Published 2015-08-01

Susceptibility of European red deer (Cervus elaphus elaphus) to alimentary challenge with bovine spongiform encephalopathy.

by Mark P Dagleish, Stuart Martin, Philip Steele, Jeanie Finlayson, Samantha L Eaton, Sílvia Sisó, Paula Stewart, Natalia Fernández-Borges, Scott Hamilton, Yvonne Pang, Francesca Chianini, Hugh W Reid, Wilfred Goldmann, Lorenzo González, Joaquín Castilla, Martin Jeffrey
Published 2015-01-01

Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.

by Ihssane Bouybayoune, Susanna Mantovani, Federico Del Gallo, Ilaria Bertani, Elena Restelli, Liliana Comerio, Laura Tapella, Francesca Baracchi, Natalia Fernández-Borges, Michela Mangieri, Cinzia Bisighini, Galina V Beznoussenko, Alessandra Paladini, Claudia Balducci, Edoardo Micotti, Gianluigi Forloni, Joaquín Castilla, Fabio Fiordaliso, Fabrizio Tagliavini, Luca Imeri, Roberto Chiesa
Published 2015-04-01

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

by Alejandro M Sevillano, Natalia Fernández-Borges, Neelam Younas, Fei Wang, Saioa R Elezgarai, Susana Bravo, Ester Vázquez-Fernández, Isaac Rosa, Hasier Eraña, David Gil, Sonia Veiga, Enric Vidal, Melissa L Erickson-Beltran, Esteban Guitián, Christopher J Silva, Romolo Nonno, Jiyan Ma, Joaquín Castilla, Jesús R Requena
Published 2018-01-01

Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis.

by Franc Llorens, Katrin Thüne, Eulàlia Martí, Eirini Kanata, Dimitra Dafou, Daniela Díaz-Lucena, Ana Vivancos, Orr Shomroni, Saima Zafar, Matthias Schmitz, Uwe Michel, Natalia Fernández-Borges, Olivier Andréoletti, José Antonio Del Río, Juana Díez, Andre Fischer, Stefan Bonn, Theodoros Sklaviadis, Juan Maria Torres, Isidre Ferrer, Inga Zerr
Published 2018-01-01

Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

by Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn, Andre Fischer, Pawel P. Liberski, Juan Maria Torres, Isidre Ferrer, Inga Zerr
Published 2017-04-01

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

by Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M. Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr
Published 2017-11-01

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.

by Hasier Eraña, Jorge M Charco, Michele A Di Bari, Carlos M Díaz-Domínguez, Rafael López-Moreno, Enric Vidal, Ezequiel González-Miranda, Miguel A Pérez-Castro, Sandra García-Martínez, Susana Bravo, Natalia Fernández-Borges, Mariví Geijo, Claudia D'Agostino, Joseba Garrido, Jifeng Bian, Anna König, Boran Uluca-Yazgi, Raimon Sabate, Vadim Khaychuk, Ilaria Vanni, Glenn C Telling, Henrike Heise, Romolo Nonno, Jesús R Requena, Joaquín Castilla
Published 2019-10-01