Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

by Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, Nigel Yarlett, Marcel Kaiser, Reto Brun, Tien L. Huang
Published 2016-04-01

2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.

by Luke Mercer, Tana Bowling, Joe Perales, Jennifer Freeman, Tien Nguyen, Cyrus Bacchi, Nigel Yarlett, Robert Don, Robert Jacobs, Bakela Nare
Published 2011-01-01

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

by Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D. Lykins, Martin J. McPhillie, Rajendra Upadhya, Patrick M. Woster, Nigel Yarlett, Kami Kim, Kami Kim, Louis M. Weiss, Louis M. Weiss
Published 2019-02-01

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

by Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don
Published 2011-06-01