Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors.

by Bijay S Jaiswal, Vasantharajan Janakiraman, Noelyn M Kljavin, Jeffrey Eastham-Anderson, James E Cupp, Yuxin Liang, David P Davis, Klaus P Hoeflich, Somasekar Seshagiri
Published 2009-05-01

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis

by Wenlin Yuan, Leonard D. Goldstein, Steffen Durinck, Ying-Jiun Chen, Thong T. Nguyen, Noelyn M. Kljavin, Ethan S. Sokol, Eric W. Stawiski, Benjamin Haley, James Ziai, Zora Modrusan, Somasekar Seshagiri
Published 2019-12-01