POS-370 HUMAN RENAL MESANGIAL CELL ACTIVATION INDUCED BY ENDOTHELIN-1 OR IGA NEPHROPATHY PATIENT-DERIVED IMMUNE COMPLEXES IS BLOCKED BY SELECTIVE ETA ANTAGONIST ATRASENTAN

by J. COX, J. Wu, N. Naidu, M. Gunawan, O. Chong, A. King
Published 2021-04-01

POS-378 SELECTIVE ETA ANTAGONIST ATRASENTAN, RAPIDLY REDUCES ALBUMINURIA AND DOWNREGULATES INTRA-RENAL PRO-INFLAMMATORY AND PRO-FIBROTIC TRANSCRIPTIONAL NETWORKS IN THE GDDY MOUSE...

by A. KING, R. Oballa, M. Gunawan, J. Cox, J. Wu, O. Chong, J. Surendradoss, J. Lester, C. Nieh, T. Kano, Y. Suzuki
Published 2021-04-01

POS-442 DISCOVERY OF CHK-336: A FIRST-IN-CLASS, LIVER-TARGETED, SMALL MOLECULE INHIBITOR OF LACTATE DEHYDROGENASE FOR THE TREATMENT OF PRIMARY HYPEROXALURIA

by J. COX, M.O. Boily, A. Caron, O. Chong, J. Ding, V. Dumais, S. Gaudreault, R. Gomez, J. Guthrie, A. King, R. Oballa, T. Sheng, J. Surendradoss, J. Wu, D. Powell
Published 2021-04-01