EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.

by Serge A L Zander, Wendy Sol, Lee Greenberger, Yixian Zhang, Olaf van Tellingen, Jos Jonkers, Piet Borst, Sven Rottenberg
Published 2012-01-01

Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness

by Nora Pencheva, Mark C. de Gooijer, Daniel J. Vis, Lodewyk F.A. Wessels, Tom Würdinger, Olaf van Tellingen, René Bernards
Published 2017-07-01

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2

by Mark C. de Gooijer, Nienke A. de Vries, Tessa Buckle, Levi C.M. Buil, Jos H. Beijnen, Willem Boogerd, Olaf van Tellingen
Published 2018-07-01

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

by Nienke A. de Vries, Danielle Hulsman, Waseem Akhtar, Johann de Jong, Denise C. Miles, Marleen Blom, Olaf van Tellingen, Jos Jonkers, Maarten van Lohuizen
Published 2015-01-01

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101).

by Pieter J Gaillard, Chantal C M Appeldoorn, Rick Dorland, Joan van Kregten, Francesca Manca, Danielle J Vugts, Bert Windhorst, Guus A M S van Dongen, Helga E de Vries, David Maussang, Olaf van Tellingen
Published 2014-01-01

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

by João M. Fernandes Neto, Ernest Nadal, Evert Bosdriesz, Salo N. Ooft, Lourdes Farre, Chelsea McLean, Sjoerd Klarenbeek, Anouk Jurgens, Hannes Hagen, Liqin Wang, Enriqueta Felip, Alex Martinez-Marti, August Vidal, Emile Voest, Lodewyk F. A. Wessels, Olaf van Tellingen, Alberto Villanueva, René Bernards
Published 2020-06-01

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

by Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C. de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H. W. Crommentuijn, Laurine E. Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H. van der Meulen-Muileman, Rogier M. Reijmers, Toin H. van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A. Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W. Peter Vandertop, David P. Noske, Victor W. van Beusechem, Jacco van Rheenen, D. Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger
Published 2018-12-01