Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site

by Natalia A. Lebedeva, Nadejda I. Rechkunova, Anton V. Endutkin, Olga I. Lavrik, Olga I. Lavrik
Published 2021-01-01

Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

by Maria V. Sukhanova, Anastasia S. Singatulina, David Pastré, Olga I. Lavrik
Published 2020-09-01

RPA and XPA interaction with DNA structures mimicking intermediates of the late stages in nucleotide excision repair.

by Yuliya S Krasikova, Nadejda I Rechkunova, Ekaterina A Maltseva, Olga I Lavrik
Published 2018-01-01

Abstract P-16: Interaction of Poly(ADP-Ribose)Polymerase1 and Poly(ADP-Ribose)Polymerase2 with Nucleosome during Base Excision Repair

by Mikhail M. Kutuzov, Ekaterina A. Belousova, Olga I. Lavrik, Svetlana N. Khodyreva
Published 2019-06-01

Abstract P-21: The Oligomeric State of Base Excision DNA Repair Proteins and Their Complexes Explored by Dynamic Light Scattering

by Inna A. Vasil’eva, Nina A. Moor, Rashid O. Anarbaev, Olga I. Lavrik
Published 2019-06-01

PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins

by Nikita V. Savelyev, Nikita V. Savelyev, Nikita M. Shepelev, Olga I. Lavrik, Olga I. Lavrik, Maria P. Rubtsova, Maria P. Rubtsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova
Published 2021-05-01

Clustered DNA lesions containing 5-formyluracil and AP site: repair via the BER system.

by Ekaterina A Belousova, Inna A Vasil'eva, Nina A Moor, Timofey S Zatsepin, Tatiana S Oretskaya, Olga I Lavrik
Published 2013-01-01

PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

by Anastasia S. Singatulina, Loic Hamon, Maria V. Sukhanova, Bénédicte Desforges, Vandana Joshi, Ahmed Bouhss, Olga I. Lavrik, David Pastré
Published 2019-05-01

Strand Displacement Activity of PrimPol

by Elizaveta O. Boldinova, Ekaterina A. Belousova, Diana I. Gagarinskaya, Ekaterina A. Maltseva, Svetlana N. Khodyreva, Olga I. Lavrik, Alena V. Makarova
Published 2020-11-01

Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1

by Konstantin N. Naumenko, Mariya V. Sukhanova, Loic Hamon, Tatyana A. Kurgina, Elizaveta E. Alemasova, Mikhail M. Kutuzov, David Pastré, Olga I. Lavrik
Published 2020-09-01

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

by Alexandra L. Zakharenko, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Georgy A. Ivanov, Vladimir E. Oslovsky, Ekaterina S. Ilina, Irina A. Chernyshova, Olga I. Lavrik, Sergey N. Mikhailov
Published 2020-08-01

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

by Anastasia O. Komarova, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Irina V. Kulikova, Vladimir E. Oslovsky, Olga D. Zakharova, Alexandra L. Zakharenko, Sergey N. Mikhailov, Olga I. Lavrik
Published 2018-01-01

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

by Elizaveta D. Gladkova, Arina A. Chepanova, Ekaterina S. Ilina, Alexandra L. Zakharenko, Jóhannes Reynisson, Olga A. Luzina, Konstantin P. Volcho, Olga I. Lavrik, Nariman F. Salakhutdinov
Published 2021-03-01

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

by Nikolai S. Li-Zhulanov, Alexandra L. Zakharenko, Arina A. Chepanova, Jinal Patel, Ayesha Zafar, Konstantin P. Volcho, Nariman F. Salakhutdinov, Jóhannes Reynisson, Ivanhoe K. H. Leung, Olga I. Lavrik
Published 2018-09-01

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

by Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2021-07-01

Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus

by Dmitry A. Kretov, Daria A. Mordovkina, Irina A. Eliseeva, Dmitry N. Lyabin, Dmitry N. Polyakov, Vandana Joshi, Bénédicte Desforges, Loic Hamon, Olga I. Lavrik, David Pastré, Patrick A. Curmi, Lev P. Ovchinnikov
Published 2019-12-01

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

by Oksana V. Salomatina, Irina I. Popadyuk, Alexandra L. Zakharenko, Olga D. Zakharova, Dmitriy S. Fadeev, Nina I. Komarova, Jóhannes Reynisson, H. John Arabshahi, Raina Chand, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2018-03-01

The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1

by Alexey V. Beletsky, Alexander N. Malyavko, Maria V. Sukhanova, Eugenia S. Mardanova, Maria I. Zvereva, Olga A. Petrova, Yulia Yu. Parfenova, Maria P. Rubtsova, Andrey V. Mardanov, Olga I. Lavrik, Olga A. Dontsova, Nikolai V. Ravin
Published 2017-06-01

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments

by Aldar A. Munkuev, Evgenii S. Mozhaitsev, Arina A. Chepanova, Evgeniy V. Suslov, Dina V. Korchagina, Olga D. Zakharova, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2021-05-01

The First Berberine-based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

by Elizaveta D. Gladkova, Ivan V. Nechepurenko, Roman A. Bredikhin, Arina A. Chepanova, Alexandra L. Zakharenko, Olga A. Luzina, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Evgeniya M. Mamontova, Rashid O. Anarbaev, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2020-09-01