Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

by Oliver T. Fackler
Published 2015-12-01

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

by Oliver T. Fackler, Bettina Stolp
Published 2011-03-01

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.

by Claudia Haller, Susanne Rauch, Oliver T Fackler
Published 2007-11-01

Environmental Restrictions: A New Concept Governing HIV-1 Spread Emerging from Integrated Experimental-Computational Analysis of Tissue-Like 3D Cultures

by Samy Sid Ahmed, Nils Bundgaard, Frederik Graw, Oliver T. Fackler
Published 2020-04-01

FAMoS: A Flexible and dynamic Algorithm for Model Selection to analyse complex systems dynamics.

by Michael Gabel, Tobias Hohl, Andrea Imle, Oliver T Fackler, Frederik Graw
Published 2019-08-01

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.

by Sebastian Breuer, Simone I Schievink, Antje Schulte, Wulf Blankenfeldt, Oliver T Fackler, Matthias Geyer
Published 2011-01-01

Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils

by Tatjana Reif, Gerhard Dyckhoff, Ralph Hohenberger, Carl-Christian Kolbe, Henning Gruell, Florian Klein, Eicke Latz, Bettina Stolp, Oliver T. Fackler
Published 2021-06-01

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.

by Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T Fackler, Seiji Okada, Shinya Suzu
Published 2011-01-01

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

by Christian Ostalecki, Sebastian Wittki, Jung-Hyun Lee, Miriam M. Geist, Nadine Tibroni, Thomas Harrer, Gerold Schuler, Oliver T. Fackler, Andreas S. Baur
Published 2016-11-01

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.

by Marta Martínez-Bonet, Claudia Palladino, Veronica Briz, Jochen M Rudolph, Oliver T Fackler, Miguel Relloso, Maria Angeles Muñoz-Fernandez, Ricardo Madrid
Published 2015-01-01

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

by Ying Wang, Alice Sherrard, Bing Zhao, Michael Melak, Jonathan Trautwein, Eva-Maria Kleinschnitz, Nikolaos Tsopoulidis, Oliver T. Fackler, Carsten Schwan, Robert Grosse
Published 2019-11-01

Erratum for Roth et al., “Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses”

by Hanna Roth, Vera Magg, Fabian Uch, Pascal Mutz, Philipp Klein, Katharina Haneke, Volker Lohmann, Ralf Bartenschlager, Oliver T. Fackler, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri
Published 2017-04-01

SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

by Ariane Zutz, Christian Schölz, Stephanie Schneider, Virginia Pierini, Maximilian Münchhoff, Kathrin Sutter, Georg Wittmann, Ulf Dittmer, Rika Draenert, Johannes R. Bogner, Oliver T. Fackler, Oliver T. Keppler
Published 2020-01-01

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

by Hanna Roth, Vera Magg, Fabian Uch, Pascal Mutz, Philipp Klein, Katharina Haneke, Volker Lohmann, Ralf Bartenschlager, Oliver T. Fackler, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri, Michael J. Buchmeier
Published 2017-01-01

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.

by Jingyan Chen, Nadine Tibroni, Daniel Sauter, Johanna Galaski, Toshiyuki Miura, Galit Alter, Birthe Mueller, Claudia Haller, Bruce D Walker, Frank Kirchhoff, Zabrina L Brumme, Takamasa Ueno, Oliver T Fackler
Published 2015-01-01

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

by Andrea Imle, Peter Kumberger, Nikolas D. Schnellbächer, Jana Fehr, Paola Carrillo-Bustamante, Janez Ales, Philip Schmidt, Christian Ritter, William J. Godinez, Barbara Müller, Karl Rohr, Fred A. Hamprecht, Ulrich S. Schwarz, Frederik Graw, Oliver T. Fackler
Published 2019-05-01

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

by Dorota Kmiec, Bengisu Akbil, Swetha Ananth, Dominik Hotter, Konstantin M J Sparrer, Christina M Stürzel, Birthe Trautz, Ahidjo Ayouba, Martine Peeters, Zhong Yao, Igor Stagljar, Vânia Passos, Thomas Zillinger, Christine Goffinet, Daniel Sauter, Oliver T Fackler, Frank Kirchhoff
Published 2018-08-01

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.

by Daniel Sauter, Daniel Unterweger, Michael Vogl, Shariq M Usmani, Anke Heigele, Silvia F Kluge, Elisabeth Hermkes, Markus Moll, Edward Barker, Martine Peeters, Gerald H Learn, Frederic Bibollet-Ruche, Joëlle V Fritz, Oliver T Fackler, Beatrice H Hahn, Frank Kirchhoff
Published 2012-12-01

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

by Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter
Published 2019-05-01