The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity.

by Pablo C Echeverria, Kaushik Bhattacharya, Abhinav Joshi, Tai Wang, Didier Picard
Published 2019-01-01

An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.

by Pablo C Echeverría, Andreas Bernthaler, Pierre Dupuis, Bernd Mayer, Didier Picard
Published 2011-01-01

Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

by Gregory Segala, Marcela A. Bennesch, Nastaran Mohammadi Ghahhari, Deo Prakash Pandey, Pablo C. Echeverria, François Karch, Robert K. Maeda, Didier Picard
Published 2019-04-01

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

by Kaushik Bhattacharya, Lorenz Weidenauer, Tania Morán Luengo, Ellis C. Pieters, Pablo C. Echeverría, Lilia Bernasconi, Diana Wider, Yashar Sadian, Margreet B. Koopman, Matthieu Villemin, Christoph Bauer, Stefan G. D. Rüdiger, Manfredo Quadroni, Didier Picard
Published 2020-11-01