53BP1 Compliant mechanisms DDR foci dynamics DNA damage response Electromagnetic force compensations High-precision High-vacuum conditions Mechanical modeling Mechanisms Monolithics New mechanisms Nominal loads Open modification search PDS5A Protein modifications Proteome coverage Sample preparation protocols Stiffness Weighing Yeast de novo sequencing functional single-cell selection phenotype-to-proteome linking phototagging single-cell proteomics tumor heterogeneity ultrawide field-of-view optical microscope