Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.

by Shao-Qing Kuang, Zhihong Fang, Patrick A Zweidler-McKay, Hui Yang, Yue Wei, Emilio A Gonzalez-Cervantes, Yanis Boumber, Guillermo Garcia-Manero
Published 2013-01-01

Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.

by Juliana Benito, Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Boehm, Hongbo Lu, Sergej Konoplev, Wendy Fang, Patrick A Zweidler-McKay, Dario Campana, Gautam Borthakur, Carlos Bueso-Ramos, Elizabeth Shpall, Deborah A Thomas, Craig T Jordan, Hagop Kantarjian, William R Wilson, Richard Lock, Michael Andreeff, Marina Konopleva
Published 2011-01-01

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199

by Juliana M. Benito, Laura Godfrey, Kensuke Kojima, Leah Hogdal, Mark Wunderlich, Huimin Geng, Isabel Marzo, Karine G. Harutyunyan, Leonard Golfman, Phillip North, Jon Kerry, Erica Ballabio, Triona Ní Chonghaile, Oscar Gonzalo, Yihua Qiu, Irmela Jeremias, LaKiesha Debose, Eric O’Brien, Helen Ma, Ping Zhou, Rodrigo Jacamo, Eugene Park, Kevin R. Coombes, Nianxiang Zhang, Deborah A. Thomas, Susan O’Brien, Hagop M. Kantarjian, Joel D. Leverson, Steven M. Kornblau, Michael Andreeff, Markus Müschen, Patrick A. Zweidler-McKay, James C. Mulloy, Anthony Letai, Thomas A. Milne, Marina Konopleva
Published 2015-12-01