Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.

by Céline Delloye-Bourgeois, Benjamin Gibert, Nicolas Rama, Jean-Guy Delcros, Nicolas Gadot, Jean-Yves Scoazec, Robert Krauss, Agnès Bernet, Patrick Mehlen
Published 2013-01-01

Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein ResponseSummary

by Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-López, Maud Michelet, Benjamin Ducarouge, Alfredo Berzal-Herranz, Fabien Zoulim, Patrick Mehlen, Romain Parent
Published 2016-05-01

Analysis of the dominant effects mediated by wild type or R120G mutant of αB-crystallin (HspB5) towards Hsp27 (HspB1).

by Stéphanie Simon, Valeriya Dimitrova, Benjamin Gibert, Sophie Virot, Nicole Mounier, Mathieu Nivon, Carole Kretz-Remy, Véronique Corset, Patrick Mehlen, André-Patrick Arrigo
Published 2013-01-01

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

by Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasure
Published 2018-05-01

Non-canonical NOTCH3 signalling limits tumour angiogenesis

by Shuheng Lin, Ana Negulescu, Sirisha Bulusu, Benjamin Gibert, Jean-Guy Delcros, Benjamin Ducarouge, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Pierre Saintigny, Olivier Meurette, Patrick Mehlen
Published 2017-07-01

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis.

by Francesco Napoletano, Benjamin Gibert, Keren Yacobi-Sharon, Stéphane Vincent, Clémentine Favrot, Patrick Mehlen, Victor Girard, Margaux Teil, Gilles Chatelain, Ludivine Walter, Eli Arama, Bertrand Mollereau
Published 2017-09-01

Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases.

by Patrick N Harter, Jenny Zinke, Alexander Scholz, Julia Tichy, Cornelia Zachskorn, Hans M Kvasnicka, Benjamin Goeppert, Céline Delloye-Bourgeois, Elke Hattingen, Christian Senft, Joachim P Steinbach, Karl H Plate, Patrick Mehlen, Dorothea Schulte, Michel Mittelbronn
Published 2014-01-01

Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus.

by Marie-Laure Plissonnier, Thomas Lahlali, Maud Michelet, Fanny Lebossé, Jessica Cottarel, Melanie Beer, Grégory Neveu, David Durantel, Birke Bartosch, Rosita Accardi, Sophie Clément, Andrea Paradisi, Mojgan Devouassoux-Shisheboran, Shirit Einav, Patrick Mehlen, Fabien Zoulim, Romain Parent
Published 2016-03-01

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

by Davide Pradella, Gianluca Deflorian, Alex Pezzotta, Anna Di Matteo, Elisa Belloni, Daniele Campolungo, Andrea Paradisi, Mattia Bugatti, William Vermi, Matteo Campioni, Antonella Chiapparino, Luigi Scietti, Federico Forneris, Costanza Giampietro, Nina Volf, Michael Rehman, Serena Zacchigna, Maria Paola Paronetto, Anna Pistocchi, Anne Eichmann, Patrick Mehlen, Claudia Ghigna
Published 2021-08-01

Targeting netrin‐3 in small cell lung cancer and neuroblastoma

by Shan Jiang, Mathieu Richaud, Pauline Vieugué, Nicolas Rama, Jean‐Guy Delcros, Maha Siouda, Mitsuaki Sanada, Anna‐Rita Redavid, Benjamin Ducarouge, Maëva Hervieu, Silvia Breusa, Ambroise Manceau, Charles‐Henry Gattolliat, Nicolas Gadot, Valérie Combaret, David Neves, Sandra Ortiz‐Cuaran, Pierre Saintigny, Olivier Meurette, Thomas Walter, Isabelle Janoueix‐Lerosey, Paul Hofman, Peter Mulligan, David Goldshneider, Patrick Mehlen, Benjamin Gibert
Published 2021-04-01

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

by Raphael Reuten, Trushar R. Patel, Matthew McDougall, Nicolas Rama, Denise Nikodemus, Benjamin Gibert, Jean-Guy Delcros, Carina Prein, Markus Meier, Stéphanie Metzger, Zhigang Zhou, Jennifer Kaltenberg, Karen K. McKee, Tobias Bald, Thomas Tüting, Paola Zigrino, Valentin Djonov, Wilhelm Bloch, Hauke Clausen-Schaumann, Ernst Poschl, Peter D. Yurchenco, Martin Ehrbar, Patrick Mehlen, Jörg Stetefeld, Manuel Koch
Published 2016-11-01

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

by Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Published 2021-01-01