Paul A. Sieving
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Sieving is recognized for translational medicine studies of human progressive, blinding, inherited retinal and macular neurodegeneration diseases, including retinitis pigmentosa and Stargardt disease. His laboratory studies the conditions in transgenic animal models in pursuit of pharmacological approaches to slowing degeneration in people with the disorders. His group conducted the first human clinical trial of ciliary neurotrophic factor (CNTF) as a rescue factor for retinitis pigmentosa.
His lab studies potential treatments for a juvenile form of macular degeneration termed X-linked retinoschisis (XLRS). The lab developed a mouse model of XLRS and successfully treated the condition by gene therapy in mouse and rabbit models. Sieving's team, in coordination with the clinical staff at the National Institutes of Health Clinical Center, is conducting a phase 1 clinical trial to test the therapy in XLRS patients. He maintains a small clinical practice at NEI for patients with these and other genetic retinal diseases, including Stargardt juvenile macular degeneration.
Sieving established the NEI Audacious Goals Initiative (AGI) for Regenerative Medicine, a major program to develop treatments for eye diseases. The AGI is a strategic research effort to restore function of critical nerve cells in the eye and visual system even after they are damaged by disease. Success will mean new approaches to prevent and even reverse vision loss in diseases such as age-related macular degeneration and glaucoma. Provided by Wikipedia
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1by Shobi Veleri, Csilla H. Lazar, Bo Chang, Paul A. Sieving, Eyal Banin, Anand SwaroopGet full text
Published 2015-02-01
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4by Azamat Aslanukov, Reshma Bhowmick, Mallikarjuna Guruju, John Oswald, Dorit Raz, Ronald A Bush, Paul A Sieving, Xinrong Lu, Cheryl B Bock, Paulo A FerreiraGet full text
Published 2006-10-01
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5by Catherine Cukras, Terry Gaasterland, Pauline Lee, Harini V Gudiseva, Venkata R M Chavali, Raghu Pullakhandam, Bruno Maranhao, Lee Edsall, Sandra Soares, G Bhanuprakash Reddy, Paul A Sieving, Radha AyyagariGet full text
Published 2012-01-01
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6by Dario Marangoni, Ronald A Bush, Yong Zeng, Lisa L Wei, Lucia Ziccardi, Camasamudram Vijayasarathy, Joshua T Bartoe, Kiran Palyada, Maria Santos, Suja Hiriyanna, Zhijian Wu, Peter Colosi, Paul A SievingGet full text
Published 2016-01-01
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7by Lin Li, Xiaodong Jiao, Ilaria D'Atri, Fumihito Ono, Ralph Nelson, Chi-Chao Chan, Naoki Nakaya, Zhiwei Ma, Yan Ma, Xiaoying Cai, Longhua Zhang, Siying Lin, Abdul Hameed, Barry A Chioza, Holly Hardy, Gavin Arno, Sarah Hull, Muhammad Imran Khan, James Fasham, Gaurav V Harlalka, Michel Michaelides, Anthony T Moore, Zeynep Hande Coban Akdemir, Shalini Jhangiani, James R Lupski, Frans P M Cremers, Raheel Qamar, Ahmed Salman, John Chilton, Jay Self, Radha Ayyagari, Firoz Kabir, Muhammad Asif Naeem, Muhammad Ali, Javed Akram, Paul A Sieving, Sheikh Riazuddin, Emma L Baple, S Amer Riazuddin, Andrew H Crosby, J Fielding HejtmancikGet full text
Published 2018-08-01
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