Small-Molecule Procaspase‑3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

by Rachel C. Botham, Howard S. Roth, Alison P. Book, Patrick J. Roady, Timothy M. Fan, Paul J. Hergenrother
Published 2016-07-01

Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers

by Lisa J. Schlein, Bahaa Fadl-Alla, Holly C. Pondenis, Stéphane Lezmi, Charles G. Eberhart, Amy K. LeBlanc, Peter J. Dickinson, Paul J. Hergenrother, Timothy M. Fan
Published 2019-02-01

Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy

by Alycen P. Lundberg, Matthew W. Boudreau, Kim A. Selting, Lindsay E. Chatkewitz, Jonathan Samuelson, Joshua M. Francis, Elizabeth I. Parkinson, Anne M. Barger, Paul J. Hergenrother, Timothy M. Fan
Published 2021-08-01

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

by Rahul Palchaudhuri, Michael J. Lambrecht, Rachel C. Botham, Kathryn C. Partlow, Tjakko J. van Ham, Karson S. Putt, Laurie T. Nguyen, Seok-Ho Kim, Randall T. Peterson, Timothy M. Fan, Paul J. Hergenrother
Published 2015-12-01

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

by Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J. Hergenrother, Stefan R. Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek Pratt, Michael Gütschow, Marcus Conrad, Andreas Linkermann
Published 2021-07-01