For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors

by Christina M. Buchanan, Kate L. Lee, Peter R. Shepherd
Published 2019-08-01

β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding

by Stewart W.C. Masson, Brie Sorrenson, Peter R. Shepherd, Troy L. Merry
Published 2020-12-01

Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase

by James M. J. Dickson, Woo‑Jeong Lee, Peter R. Shepherd, Christina M. Buchanan
Published 2013-11-01

Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in animal cancer models

by Qian Wang, William Gavin, Nicholas Masiello, Khanh B. Tran, Götz Laible, Peter R. Shepherd
Published 2020-12-01

Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

by Christopher P. Hedges, Jordi Boix, Jagdish K. Jaiswal, Bhoopika Shetty, Peter R. Shepherd, Troy L. Merry
Published 2021-01-01

Inhibitors of pan PI3K signaling synergize with BRAF or MEK inhibitors to prevent BRAF-mutant melanoma cell growth

by Melanie eSweetlove, Melanie eSweetlove, Emma eWrightson, Sharada eKolekar, Gordon W. Rewcastle, Gordon W. Rewcastle, Bruce C. Baguley, Bruce C. Baguley, Peter R. Shepherd, Peter R. Shepherd, Stephen M. F. Jamieson, Stephen M. F. Jamieson
Published 2015-06-01

Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.

by Christina M Buchanan, James M J Dickson, Woo-Jeong Lee, Mark A Guthridge, Jackie D Kendall, Peter R Shepherd
Published 2013-01-01

Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK

by Khanh B. Tran, Sharada Kolekar, Anower Jabed, Patrick Jaynes, Jen-Hsing Shih, Qian Wang, Jack U. Flanagan, Gordon W. Rewcastle, Bruce C. Baguley, Peter R. Shepherd
Published 2021-02-01

Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

by AlexanderJ. Trevarton, Yan Zhou, Dehua Yang, Gordon W. Rewcastle, Jack U. Flanagan, Antony Braithwaite, Peter R. Shepherd, Cristin G. Print, Ming-Wei Wang, Annette Lasham
Published 2019-09-01

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model

by Denver D. Britto, Barbara Wyroba, Wenxuan Chen, Rhoswen A. Lockwood, Khanh B. Tran, Peter R. Shepherd, Christopher J. Hall, Kathryn E. Crosier, Philip S. Crosier, Jonathan W. Astin
Published 2018-12-01

Correction: Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

by Janice B. B. Lam, Kim H. M. Chow, Aimin Xu, Karen S. L. Lam, Jing Liu, Nai-Sum Wong, Randall T. Moon, Peter R. Shepherd, Garth J. S. Cooper, Yu Wang
Published 2009-01-01

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.

by Janice B B Lam, Kim H M Chow, Aimin Xu, Karen S L Lam, Jing Liu, Nai-Sum Wong, Randall T Moon, Peter R Shepherd, Garth J S Cooper, Yu Wang
Published 2009-01-01

Correction: Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities.

by Janice B. B. Lam, Kim H. M. Chow, Aimin Xu, Karen S. L. Lam, Jing Liu, Nai-Sum Wong, Randall T. Moon, Peter R. Shepherd, Garth J. S. Cooper, Yu Wang
Published 2009-01-01

Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

by Katrin Höland, Danielle Boller, Christian Hagel, Silvia Dolski, András Treszl, Olivier E Pardo, Paulina Cwiek, Fabiana Salm, Zaira Leni, Peter R Shepherd, Beata Styp-Rekowska, Valentin Djonov, André O von Bueren, Karl Frei, Alexandre Arcaro
Published 2014-01-01

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.

by Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew C W Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge
Published 2013-01-01