The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits

by Grant Richter, Vivian W. Y. Liao, Philip K. Ahring, Mary Chebib
Published 2020-11-01

Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation

by Sebastian Oddsson, Natalia M. Kowal, Philip K. Ahring, Elin S. Olafsdottir, Thomas Balle
Published 2020-06-01

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.

by Jeppe A Olsen, Thomas Balle, Michael Gajhede, Philip K Ahring, Jette S Kastrup
Published 2014-01-01

Novel Approach for the Search for Chemical Scaffolds with Activity at Both Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor: A Perspective on Scaffolds with Dual Ac...

by Natalia M. Kowal, Dinesh C. Indurthi, Philip K. Ahring, Mary Chebib, Elin S. Olafsdottir, Thomas Balle
Published 2019-01-01

Ligand Binding at the 4-4 Agonist-Binding Site of the 42 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State.

by Dinesh C Indurthi, Trevor M Lewis, Philip K Ahring, Thomas Balle, Mary Chebib, Nathan L Absalom
Published 2016-01-01

The Delta-Subunit Selective GABAA Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism

by Silke Neumann, Silke Neumann, Lily Boothman-Burrell, Emma K. Gowing, Thomas A. Jacobsen, Philip K. Ahring, Sarah L. Young, Karin Sandager-Nielsen, Andrew N. Clarkson
Published 2019-10-01