Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA.

by Wilko Duprez, Prabhakar Bachu, Martin J Stoermer, Stephanie Tay, Róisín M McMahon, David P Fairlie, Jennifer L Martin
Published 2015-01-01

Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development.

by Signe Christensen, Maria A Halili, Natalie Strange, Guillaume A Petit, Wilhelmina M Huston, Jennifer L Martin, Róisín M McMahon
Published 2019-01-01

Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase.

by Signe Christensen, Morten K Grøftehauge, Karl Byriel, Wilhelmina M Huston, Emily Furlong, Begoña Heras, Jennifer L Martin, Róisín M McMahon
Published 2016-01-01

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1.

by Biswaranjan Mohanty, Kieran Rimmer, Róisín M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coinçon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon
Published 2017-01-01