Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

by Rachael E Hawtin, David E Stockett, Jo Ann W Byl, Robert S McDowell, Tan Nguyen, Michelle R Arkin, Andrew Conroy, Wenjin Yang, Neil Osheroff, Judith A Fox
Published 2010-04-01

Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status.

by Alessandra Cesano, Santosh Putta, David B Rosen, Aileen C Cohen, Urte Gayko, Kavita Mathi, John Woronicz, Rachael E Hawtin, Larry Cripe, Zhuoxin Sun, Martin S Tallman, Elisabeth Paietta
Published 2013-01-01

Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

by Silvia C. Formenti, Rachael E. Hawtin, Neha Dixit, Erik Evensen, Percy Lee, Judith D. Goldberg, Xiaochun Li, Claire Vanpouille-Box, Dörthe Schaue, William H. McBride, Sandra Demaria
Published 2019-07-01

AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin.

by David B Rosen, Kimberly H Harrington, James A Cordeiro, Ling Y Leung, Santosh Putta, Norman Lacayo, George S Laszlo, Chelsea J Gudgeon, Donna E Hogge, Rachael E Hawtin, Alessandra Cesano, Roland B Walter
Published 2013-01-01

Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity.

by Jason Ptacek, Rachael E Hawtin, Dongmei Sun, Brent Louie, Erik Evensen, Barbara B Mittleman, Alessandra Cesano, Guy Cavet, Clifton O Bingham, Stacey S Cofield, Jeffrey R Curtis, Maria I Danila, Chander Raman, Richard A Furie, Mark C Genovese, William H Robinson, Marc C Levesque, Larry W Moreland, Peter A Nigrovic, Nancy A Shadick, James R O'Dell, Geoffrey M Thiele, E William St Clair, Christopher C Striebich, Matthew B Hale, Houman Khalili, Franak Batliwalla, Cynthia Aranow, Meggan Mackay, Betty Diamond, Garry P Nolan, Peter K Gregersen, S Louis Bridges
Published 2021-01-01