R-spondins can potentiate WNT signaling without LGRs

by Andres M Lebensohn, Rajat Rohatgi
Published 2018-02-01

In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes

by Hermann Broder Schmidt, Rajat Rohatgi
Published 2016-08-01

Phase separation-deficient TDP43 remains functional in splicing

by Hermann Broder Schmidt, Ariana Barreau, Rajat Rohatgi
Published 2019-10-01

Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens.

by Bhaven B Patel, Andres M Lebensohn, Ganesh V Pusapati, Jan E Carette, Julia Salzman, Rajat Rohatgi
Published 2019-01-01

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

by Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Published 2016-10-01

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

by Pawel Niewiadomski, Jennifer H. Kong, Robert Ahrends, Yan Ma, Eric W. Humke, Sohini Khan, Mary N. Teruel, Bennett G. Novitch, Rajat Rohatgi
Published 2014-01-01

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

by Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Published 2013-10-01

Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.

by Suresh Marada, Gemma Navarro, Ashley Truong, Daniel P Stewart, Angela M Arensdorf, Sigrid Nachtergaele, Edgar Angelats, Joseph T Opferman, Rajat Rohatgi, Peter J McCormick, Stacey K Ogden
Published 2015-08-01

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

by Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi
Published 2020-05-01

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

by Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Published 2019-10-01

Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

by Andres M Lebensohn, Ramin Dubey, Leif R Neitzel, Ofelia Tacchelly-Benites, Eungi Yang, Caleb D Marceau, Eric M Davis, Bhaven B Patel, Zahra Bahrami-Nejad, Kyle J Travaglini, Yashi Ahmed, Ethan Lee, Jan E Carette, Rajat Rohatgi
Published 2016-12-01

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

by Shi-Rong Hong, Cuei-Ling Wang, Yao-Shen Huang, Yu-Chen Chang, Ya-Chu Chang, Ganesh V. Pusapati, Chun-Yu Lin, Ning Hsu, Hsiao-Chi Cheng, Yueh-Chen Chiang, Wei-En Huang, Nathan C. Shaner, Rajat Rohatgi, Takanari Inoue, Yu-Chun Lin
Published 2018-04-01

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

by Michaela Bosakova, Sara P Abraham, Alexandru Nita, Eva Hruba, Marcela Buchtova, S Paige Taylor, Ivan Duran, Jorge Martin, Katerina Svozilova, Tomas Barta, Miroslav Varecha, Lukas Balek, Jiri Kohoutek, Tomasz Radaszkiewicz, Ganesh V Pusapati, Vitezslav Bryja, Eric T Rush, Isabelle Thiffault, Deborah A Nickerson, Michael J Bamshad, University of Washington Center for Mendelian Genomics, Rajat Rohatgi, Daniel H Cohn, Deborah Krakow, Pavel Krejci
Published 2020-11-01