Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma.

by Shadmehr Demehri, Mitsuru Morimoto, Michael J Holtzman, Raphael Kopan
Published 2009-05-01

Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.

by Chin-Tong Ong, John R Sedy, Kenneth M Murphy, Raphael Kopan
Published 2008-07-01

In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea.

by Zhiyong Liu, Zhenyi Liu, Bradley J Walters, Thomas Owen, Raphael Kopan, Jian Zuo
Published 2013-01-01

Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice.

by Chihiro Sato, Mustafa Turkoz, Joshua T Dearborn, David F Wozniak, Raphael Kopan, Matthew R Hass
Published 2012-01-01

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets.

by Matthew R Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C Kottyan, Matthew T Weirauch, Raphael Kopan
Published 2021-06-01

Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.

by Julie M Lander, Dorothy M Supp, Hua He, Lisa J Martin, Xiaoting Chen, Matthew T Weirauch, Steven T Boyce, Raphael Kopan
Published 2017-01-01

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.

by Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M Karner, Seung-Yon Lee, Julia Heisig, Cornelia Wiese, Kameswaran Surendran, Raphael Kopan, Manfred Gessler, Fanxin Long
Published 2012-01-01

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

by Chandramouli R. Chillakuri, Devon Sheppard, Ma. Xenia G. Ilagan, Laurie R. Holt, Felicity Abbott, Shaoyan Liang, Raphael Kopan, Penny A. Handford, Susan M. Lea
Published 2013-11-01

Correction: Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity.

by Shadmehr Demehri, Zhenyi Liu, Jonghyeob Lee, Meei-Hua Lin, Seth D Crosby, Christopher J Roberts, Perry W Grigsby, Jeffrey H Miner, Andrew G Farr, Raphael Kopan
Published 2008-07-01

Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.

by Shadmehr Demehri, Zhenyi Liu, Jonghyeob Lee, Meei-Hua Lin, Seth D Crosby, Christopher J Roberts, Perry W Grigsby, Jeffrey H Miner, Andrew G Farr, Raphael Kopan
Published 2008-05-01

RNF4-Dependent Oncogene Activation by Protein Stabilization

by Jane J. Thomas, Mona Abed, Julian Heuberger, Rostislav Novak, Yaniv Zohar, Angela P. Beltran Lopez, Julie S. Trausch-Azar, Ma. Xenia G. Ilagan, David Benhamou, Gunnar Dittmar, Raphael Kopan, Walter Birchmeier, Alan L. Schwartz, Amir Orian
Published 2016-09-01

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestatio...

by Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Praneet Chaturvedi, Sarah J Stein, Warren S Pear, Zhenyu Yuan, Rhett A Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric W Brunskill, Raphael Kopan
Published 2020-10-01

Correction: Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium

by Leonor Gama-Norton, Eva Ferrando, Cristina Ruiz-Herguido, Zhenyi Liu, Jordi Guiu, Abul B. M. M. K. Islam, Sung-Uk Lee, Minhong Yan, Cynthia J. Guidos, Nuria López-Bigas, Takahiro Maeda, Lluis Espinosa, Raphael Kopan, Anna Bigas
Published 2016-03-01

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.

by Alexis Dumortier, André-Dante Durham, Matteo Di Piazza, Sophie Vauclair, Ute Koch, Gisèle Ferrand, Isabel Ferrero, Shadmehr Demehri, Lynda Li Song, Andrew G Farr, Warren J Leonard, Raphael Kopan, Lucio Miele, Daniel Hohl, Daniela Finke, Freddy Radtke
Published 2010-02-01

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

by Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein
Published 2020-04-01