A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.

by Cornelia Schuster, Helen Brosi, Katja Stifter, Bernhard O Boehm, Reinhold Schirmbeck
Published 2013-01-01

Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination

by Katja Stifter, Cornelia Schuster, Jana Krieger, Andreas Spyrantis, Bernhard Otto Boehm, Reinhold Schirmbeck
Published 2019-03-01

An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells.

by Marcin Cebula, Aaron Ochel, Upneet Hillebrand, Marina C Pils, Reinhold Schirmbeck, Hansjörg Hauser, Dagmar Wirth
Published 2013-01-01

IFN-γ treatment protocol for MHC-Ilo/PD-L1+ pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential

by Johann Gout, Thomas Seufferlein, Alexander Kleger, Katja Stifter, Jana Krieger, Leonie Ruths, Medhanie Mulaw, Andre Lechel, Martin Wagner, Reinhold Schirmbeck
Published 2020-07-01

Impaired immune surveillance accelerates accumulation of senescent cells and aging

by Yossi Ovadya, Tomer Landsberger, Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky
Published 2018-12-01

An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation

by Michael Svinarenko, Sarah-Fee Katz, Umesh Tharehalli, Medhanie A. Mulaw, Harald J. Maier, Yoshiaki Sunami, Sarah K. Fischer, Yuexin Chen, Sabine Heurich, Lena Erkert, Andrea Tannapfel, Thomas Wirth, Reinhold Schirmbeck, Thomas Seufferlein, André Lechel
Published 2019-09-01

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by <i>Rbpj</i> Deletion

by Umesh Tharehalli, Michael Svinarenko, Johann M. Kraus, Silke D. Kühlwein, Robin Szekely, Ute Kiesle, Annika Scheffold, Thomas F.E. Barth, Alexander Kleger, Reinhold Schirmbeck, Hans A. Kestler, Thomas Seufferlein, Franz Oswald, Sarah-Fee Katz, André Lechel
Published 2018-11-01

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

by Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R. Gauthier
Published 2018-04-01