Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies.

by Renata B Lacerda, Natália M Sales, Leandro L da Silva, Roberta Tesch, Ana Luisa P Miranda, Eliezer J Barreiro, Patricia D Fernandes, Carlos A M Fraga
Published 2014-01-01

Discovery of novel orally active anti-inflammatory N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that inhibit TNF-α production.

by Renata B Lacerda, Leandro L da Silva, Cleverton K F de Lima, Eduardo Miguez, Ana Luisa P Miranda, Stefan A Laufer, Eliezer J Barreiro, Carlos A M Fraga
Published 2012-01-01

LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain.

by Cleverton K F Lima, Rafael M Silva, Renata B Lacerda, Bruna L R Santos, Rafaela V Silva, Luciana S Amaral, Luís E M Quintas, Carlos A M Fraga, Eliezer J Barreiro, Marília Z P Guimaraes, Ana L P Miranda
Published 2014-01-01