Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2

by Ricardo A. P. Pádua, Yizhi Sun, Ingrid Marko, Warintra Pitsawong, John B. Stiller, Renee Otten, Dorothee Kern
Published 2018-10-01

Rescue of conformational dynamics in enzyme catalysis by directed evolution

by Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James S. Fraser
Published 2018-04-01

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

by Kalyan S. Chakrabarti, Roman V. Agafonov, Francesco Pontiggia, Renee Otten, Matthew K. Higgins, Gebhard F.X. Schertler, Daniel D. Oprian, Dorothee Kern
Published 2016-01-01

Dynamics of human protein kinase Aurora A linked to drug selectivity

by Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo AP Pádua, Xavier Meniche, Dorothee Kern
Published 2018-06-01