Antibody Libraries as Tools to Discover Functional Antibodies and Receptor Pleiotropism

by Chih-Wei Lin, Richard A. Lerner
Published 2021-04-01

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem

by Shanshan Lang, Jia Xie, Xueyong Zhu, Nicholas C. Wu, Richard A. Lerner, Ian A. Wilson
Published 2017-09-01

A new immunochemical strategy for triple-negative breast cancer therapy

by Chih-Wei Lin, Tianqing Zheng, Geramie Grande, Alex R. Nanna, Christoph Rader, Richard A. Lerner
Published 2021-07-01

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1.

by Tong Liu, Tomomi Kuwana, Hongkai Zhang, Matthew G Vander Heiden, Richard A Lerner, Donald D Newmeyer
Published 2019-06-01

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

by Nicholas C. Wu, Geramie Grande, Hannah L. Turner, Andrew B. Ward, Jia Xie, Richard A. Lerner, Ian A. Wilson
Published 2017-05-01

DNA‐Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On‐DNA Suzuki, Sonogashira, and Buchwald Reactions

by Hongtao Xu, Fei Ma, Nan Wang, Wei Hou, Huan Xiong, Fengping Lu, Jie Li, Shuyue Wang, Peixiang Ma, Guang Yang, Richard A. Lerner
Published 2019-12-01

Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart

by Kyung Ho Han, Britni M. Arlian, Chih-Wei Lin, Hyun Yong Jin, Geun-Hyung Kang, Sahmin Lee, Peter Chang-Whan Lee, Richard A. Lerner
Published 2020-01-01

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

by Nicholas C. Wu, Andrew J. Thompson, Jia Xie, Chih-Wei Lin, Corwin M. Nycholat, Xueyong Zhu, Richard A. Lerner, James C. Paulson, Ian A. Wilson
Published 2018-03-01

Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products

by Jia Xie, Shuyue Wang, Peixiang Ma, Fei Ma, Jie Li, Wei Wang, Fengping Lu, Huan Xiong, Yuang Gu, Shuning Zhang, Hongtao Xu, Guang Yang, Richard A. Lerner
Published 2020-06-01

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo

by Pingdong Tao, Yuanyuan Kuang, Yu Li, Wenping Li, Zibei Gao, Lili Liu, Min Qiang, Zhao Zha, Kun Fan, Peixiang Ma, Jeffrey M. Friedman, Guang Yang, Richard A. Lerner
Published 2020-08-01

Avidity‐Based Selection of Tissue‐Specific CAR‐T Cells from a Combinatorial Cellular Library of CARs

by Peixiang Ma, Ping Ren, Chuyue Zhang, Jiaxing Tang, Zheng Yu, Xuekai Zhu, Kun Fan, Guanglei Li, Wei Zhu, Wei Sang, Chenyu Min, Wenzhang Chen, Xingxu Huang, Guang Yang, Richard A. Lerner
Published 2021-03-01

Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms

by Xiaojie Shi, Yue Wan, Nan Wang, Jiangchao Xiang, Tao Wang, Xiaofeng Yang, Ju Wang, Xuxue Dong, Liang Dong, Lei Yan, Yu Li, Lili Liu, Shinchen Hou, Zhenwei Zhong, Ian A. Wilson, Bei Yang, Guang Yang, Richard A. Lerner
Published 2021-05-01

Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries.

by Arun K Kashyap, John Steel, Adam Rubrum, Angeles Estelles, Raffaella Briante, Natalia A Ilyushina, Li Xu, Ryann E Swale, Aleksandr M Faynboym, Pamela K Foreman, Michael Horowitz, Lawrence Horowitz, Richard Webby, Peter Palese, Richard A Lerner, Ramesh R Bhatt
Published 2010-07-01

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function

by Gaia Ziraldo, Gaia Ziraldo, Damiano Buratto, Yuanyuan Kuang, Liang Xu, Andrea Carrer, Andrea Carrer, Chiara Nardin, Chiara Nardin, Francesco Chiani, Anna Maria Salvatore, Gaetano Paludetti, Gaetano Paludetti, Richard A. Lerner, Guang Yang, Francesco Zonta, Fabio Mammano, Fabio Mammano, Fabio Mammano
Published 2019-06-01

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

by Liang Xu, Liang Xu, Andrea Carrer, Andrea Carrer, Francesco Zonta, Francesco Zonta, Zhihu Qu, Peixiang Ma, Sheng Li, Federico Ceriani, Federico Ceriani, Damiano Buratto, Damiano Buratto, Giulia Crispino, Giulia Crispino, Giulia Crispino, Veronica Zorzi, Veronica Zorzi, Gaia Ziraldo, Gaia Ziraldo, Gaia Ziraldo, Francesca Bruno, Francesca Bruno, Chiara Nardin, Chiara Nardin, Chiara Peres, Flavia Mazzarda, Flavia Mazzarda, Anna M. Salvatore, Marcello Raspa, Ferdinando Scavizzi, Youjun Chu, Sichun Xie, Xuemei Yang, Jun Liao, Xiao Liu, Xiao Liu, Xiao Liu, Wei Wang, Shanshan Wang, Guang Yang, Richard A. Lerner, Fabio Mammano, Fabio Mammano, Fabio Mammano, Fabio Mammano
Published 2017-09-01