Integration of Digital Pathologic and Transcriptomic Analyses Connects Tumor-Infiltrating Lymphocyte Spatial Density With Clinical Response to BRAF Inhibitors

by Arturas Ziemys, Michelle Kim, Alexander M. Menzies, Alexander M. Menzies, Alexander M. Menzies, James S. Wilmott, Georgina V. Long, Georgina V. Long, Georgina V. Long, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Larry Kwong, Ashley Holder, Ashley Holder, Genevieve Boland
Published 2020-05-01

Targeting NK Cells to Enhance Melanoma Response to Immunotherapies

by Hansol Lee, Inês Pires Da Silva, Umaimainthan Palendira, Richard A. Scolyer, Georgina V. Long, James S. Wilmott
Published 2021-03-01

Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition

by John J. Park, Russell J. Diefenbach, Natalie Byrne, Georgina V. Long, Richard A. Scolyer, Elin S. Gray, Matteo S. Carlino, Helen Rizos
Published 2021-04-01

Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients

by Mehdi R. Pirozyan, Mehdi R. Pirozyan, Mehdi R. Pirozyan, Helen M. McGuire, Helen M. McGuire, Helen M. McGuire, Abdullah Al Emran, Abdullah Al Emran, Abdullah Al Emran, Hsin-Yi Tseng, Hsin-Yi Tseng, Hsin-Yi Tseng, Jessamy C. Tiffen, Jessamy C. Tiffen, Jessamy C. Tiffen, Jenny H. Lee, Jenny H. Lee, Matteo S. Carlino, Matteo S. Carlino, Alexander M. Menzies, Alexander M. Menzies, Georgina V. Long, Georgina V. Long, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Barbara Fazekas de St Groth, Barbara Fazekas de St Groth, Barbara Fazekas de St Groth, Peter Hersey, Peter Hersey
Published 2020-03-01

Clinicopathological characteristics and management of colitis with anti-PD1 immunotherapy alone or in combination with ipilimumab

by Richard A Scolyer, Matteo Carlino, Kazi J Nahar, Robert V Rawson, Tasnia Ahmed, Stephen Tattersall, Neomal Sandanayake, Christopher J Kiely, Umaimainthan Palendira
Published 2020-07-01

PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma

by Sagun Parakh, Sagun Parakh, Sagun Parakh, Ashan Musafer, Ashan Musafer, Sabrina Paessler, Tom Witkowski, Tom Witkowski, Connie S. N. Li Wai Suen, Candani S. A. Tutuka, Matteo S. Carlino, Matteo S. Carlino, Alexander M. Menzies, Alexander M. Menzies, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Jonathan Cebon, Jonathan Cebon, Jonathan Cebon, Alexander Dobrovic, Alexander Dobrovic, Georgina V. Long, Georgina V. Long, Georgina V. Long, Oliver Klein, Oliver Klein, Andreas Behren, Andreas Behren, Andreas Behren
Published 2021-06-01

Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling.

by Andy J Chien, Lauren E Haydu, Travis L Biechele, Rima M Kulikauskas, Helen Rizos, Richard F Kefford, Richard A Scolyer, Randall T Moon, Georgina V Long
Published 2014-01-01

Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing

by Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Published 2017-05-01

Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA

by Russell J. Diefenbach, Jenny H. Lee, Alexander M. Menzies, Matteo S. Carlino, Georgina V. Long, Robyn P. M. Saw, Julie R. Howle, Andrew J. Spillane, Richard A. Scolyer, Richard F. Kefford, Helen Rizos
Published 2020-08-01

Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients

by Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Published 2017-11-01

Close proximity of immune and tumor cells underlies response to anti-PD-1 based therapies in metastatic melanoma patients

by Tuba N. Gide, Ines P. Silva, Camelia Quek, Tasnia Ahmed, Alexander M. Menzies, Matteo S. Carlino, Robyn P.M. Saw, John F. Thompson, Marcel Batten, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Published 2020-01-01

LC/MS-based quantitative proteomic analysis of paraffin-embedded archival melanomas reveals potential proteomic biomarkers associated with metastasis.

by Sharon K Huang, Marlene M Darfler, Michael B Nicholl, Jinsam You, Kerry G Bemis, Tony J Tegeler, Mu Wang, Jean-Pierre Wery, Kelly K Chong, Linhda Nguyen, Richard A Scolyer, Dave S B Hoon
Published 2009-01-01

Temporal and spatial modulation of the tumor and systemic immune response in the murine Gl261 glioma model.

by Kelly J McKelvey, Amanda L Hudson, Ramyashree Prasanna Kumar, James S Wilmott, Grace H Attrill, Georgina V Long, Richard A Scolyer, Stephen J Clarke, Helen R Wheeler, Connie I Diakos, Viive M Howell
Published 2020-01-01

Clinical and Molecular Heterogeneity in Patients with Innate Resistance to Anti-PD-1 +/− Anti-CTLA-4 Immunotherapy in Metastatic Melanoma Reveals Distinct Therapeutic Targets

by Tuba N. Gide, Inês Pires da Silva, Camelia Quek, Peter M. Ferguson, Marcel Batten, Ping Shang, Tasnia Ahmed, Alexander M. Menzies, Matteo S. Carlino, Robyn P. M. Saw, John F. Thompson, Richard A. Scolyer, Georgina V. Long, James S. Wilmott
Published 2021-06-01

Tumor MHC Expression Guides First-Line Immunotherapy Selection in Melanoma

by Elena Shklovskaya, Jenny H Lee, Su Yin Lim, Ashleigh Stewart, Bernadette Pedersen, Peter Ferguson, Robyn PM Saw, John F Thompson, Brindha Shivalingam, Matteo S Carlino, Richard A Scolyer, Alexander M Menzies, Georgina V Long, Richard F Kefford, Helen Rizos
Published 2020-11-01

SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling

by Thomas Strub, Flavia G. Ghiraldini, Saul Carcamo, Man Li, Aleksandra Wroblewska, Rajendra Singh, Matthew S. Goldberg, Dan Hasson, Zichen Wang, Stuart J. Gallagher, Peter Hersey, Avi Ma’ayan, Georgina V. Long, Richard A. Scolyer, Brian Brown, Bin Zheng, Emily Bernstein
Published 2018-08-01

Replacement and desmoplastic histopathological growth patterns in cutaneous melanoma liver metastases: frequency, characteristics, and robust prognostic value

by Raymond Barnhill, Pieter‐Jan vanDam, Peter Vermeulen, Gabriel Champenois, André Nicolas, Robert V Rawson, James S Wilmott, John F Thompson, Georgina V Long, Nathalie Cassoux, Sergio Roman‐Roman, Klaus J Busam, Richard A Scolyer, Alexander J Lazar, Claire Lugassy
Published 2020-07-01

Identifying challenges to implementation of clinical practice guidelines for sentinel lymph node biopsy in patients with melanoma in Australia: protocol paper for a mixed methods s...

by Michael Henderson, Frances Rapport, Rachael L Morton, John F Thompson, Andrea L Smith, Anne E Cust, Graham J Mann, Caroline G Watts, David E Gyorki, Angela M Hong, John W Kelly, Victoria J Mar, Robyn PM Saw, Richard A Scolyer, Andrew J Spillane
Published 2020-02-01

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

by Jenny H. Lee, Elena Shklovskaya, Su Yin Lim, Matteo S. Carlino, Alexander M. Menzies, Ashleigh Stewart, Bernadette Pedersen, Malama Irvine, Sara Alavi, Jean Y. H. Yang, Dario Strbenac, Robyn P. M. Saw, John F. Thompson, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Richard F. Kefford, Helen Rizos
Published 2020-04-01

The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis

by Mitchell S. Stark, Kerenaftali Klein, Benjamin Weide, Lauren E. Haydu, Annette Pflugfelder, Yue Hang Tang, Jane M. Palmer, David C. Whiteman, Richard A. Scolyer, Graham J. Mann, John F. Thompson, Georgina V. Long, Andrew P. Barbour, H. Peter Soyer, Claus Garbe, Adrian Herington, Pamela M. Pollock, Nicholas K. Hayward
Published 2015-07-01