G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides

by James T. Daniel, Richard J. Clark
Published 2017-11-01

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist

by Xaria X. Li, Vinod Kumar, Richard J. Clark, John D. Lee, Trent M. Woodruff
Published 2021-01-01

LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity

by Xuehan Lu, Lili Huang, Zhengxiang Huang, Dandan Feng, Dandan Feng, Richard J. Clark, Chen Chen
Published 2021-08-01

Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic <i>N</i>-Methylated Mini-Hepcidins

by Daniela Goncalves Monteiro, Johannes W. A. van Dijk, Randy Aliyanto, Eileen Fung, Elizabeta Nemeth, Tomas Ganz, Johan Rosengren, Richard J. Clark
Published 2021-02-01

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists

by Han Siean Lee, Shu Hui Wang, James T. Daniel, Mohammed Akhter Hossain, Richard J. Clark, Ross A. D. Bathgate, K. Johan Rosengren
Published 2020-10-01

Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds

by Han Siean Lee, Michael Postan, Angela Song, Richard J. Clark, Ross A. D. Bathgate, Ross A. D. Bathgate, Linda M. Haugaard-Kedström, K. Johan Rosengren
Published 2020-02-01

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR

by Yamina El Hamdaoui, Xiaosa Wu, Richard J. Clark, Julien Giribaldi, Raveendra Anangi, David J. Craik, Glenn F. King, Sebastien Dutertre, Quentin Kaas, Volker Herzig, Annette Nicke
Published 2019-05-01

Novel inhibitor cystine knot peptides from Momordica charantia.

by Wen-Jun He, Lai Yue Chan, Richard J Clark, Jun Tang, Guang-Zhi Zeng, Octavio L Franco, Cinzia Cantacessi, David J Craik, Norelle L Daly, Ning-Hua Tan
Published 2013-01-01

Helminth Immunomodulation in Autoimmune Disease

by John J. Miles, John J. Miles, John J. Miles, John J. Miles, Taylor B. Smallwood, Paul R. Giacomin, Alex Loukas, Jason P. Mulvenna, Jason P. Mulvenna, Jason P. Mulvenna, Richard J. Clark
Published 2017-04-01

ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations

by Javier Moral-Sanz, Manuel A. Fernandez-Rojo, Jeremy Potriquet, Pamela Mukhopadhyay, Andreas Brust, Patrick Wilhelm, Taylor B. Smallwood, Richard J. Clark, Bryan G. Fry, Paul F. Alewood, Nicola Waddell, John J. Miles, Jason P. Mulvenna, Maria P. Ikonomopoulou
Published 2021-02-01

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

by Aaron G. Poth, Francis C.K. Chiu, Sofie Stalmans, Brett R. Hamilton, Yen-Hua Huang, David M. Shackleford, Rahul Patil, Thao T. Le, Meng-Wei Kan, Thomas Durek, Evelien Wynendaele, Bart De Spiegeleer, Andrew K. Powell, Deon J. Venter, Richard J. Clark, Susan A. Charman, David J. Craik
Published 2021-06-01