Structural Insight into Paramyxovirus and Pneumovirus Entry Inhibition

by Megha Aggarwal, Richard K Plemper
Published 2020-03-01

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex

by Julien Sourimant, Richard K. Plemper
Published 2016-09-01

The Paramyxovirus Polymerase Complex as a Target for Next-Generation Anti-Paramyxovirus Therapeutics

by Richard K Plemper, Robert eCox
Published 2015-05-01

Biology must develop herd immunity against bad-actor molecules.

by Richard K Plemper, Robert M Cox
Published 2018-06-01

Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics.

by Venice Du Pont, Yi Jiang, Richard K Plemper
Published 2019-08-01

Structural and mechanistic studies of measles virus illuminate paramyxovirus entry.

by Richard K Plemper, Melinda A Brindley, Ronald M Iorio
Published 2011-06-01

Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics

by James P. Snyder, Richard K. Plemper, Pahk Thepchatri, Andrew Prussia
Published 2011-06-01

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.

by Robert M Cox, Julien Sourimant, Mugunthan Govindarajan, Michael G Natchus, Richard K Plemper
Published 2021-02-01

Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.

by Stefanie A Krumm, J Maina Ndungu, Jeong-Joong Yoon, Melanie Dochow, Aiming Sun, Michael Natchus, James P Snyder, Richard K Plemper
Published 2011-01-01

Promotion of virus assembly and organization by the measles virus matrix protein

by Zunlong Ke, Joshua D. Strauss, Cheri M. Hampton, Melinda A. Brindley, Rebecca S. Dillard, Fredrick Leon, Kristen M. Lamb, Richard K. Plemper, Elizabeth R. Wright
Published 2018-04-01

Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process.

by Nadine Ader-Ebert, Mojtaba Khosravi, Michael Herren, Mislay Avila, Lisa Alves, Fanny Bringolf, Claes Örvell, Johannes P Langedijk, Andreas Zurbriggen, Richard K Plemper, Philippe Plattet
Published 2015-05-01

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug th...

by T J Sego, Josua O Aponte-Serrano, Juliano Ferrari Gianlupi, Samuel R Heaps, Kira Breithaupt, Lutz Brusch, Jessica Crawshaw, James M Osborne, Ellen M Quardokus, Richard K Plemper, James A Glazier
Published 2020-12-01

Asymmetric synthesis of host-directed inhibitors of myxoviruses

by Terry W. Moore, Kasinath Sana, Dan Yan, Pahk Thepchatri, John M. Ndungu, Manohar T. Saindane, Mark A. Lockwood, Michael G. Natchus, Dennis C. Liotta, Richard K. Plemper, James P. Snyder, Aiming Sun
Published 2013-01-01

Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

by Kevin Wittwer, Danielle E. Anderson, Kristin Pfeffermann, Robert M. Cox, Josef D. Wolf, Sabine Santibanez, Annette Mankertz, Roland Plesker, Zachary M. Sticher, Alexander A. Kolkykhalov, Michael G. Natchus, Christian K. Pfaller, Richard K. Plemper, Veronika von Messling
Published 2021-09-01

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

by Michael G Currier, Sujin Lee, Christopher C Stobart, Anne L Hotard, Remi Villenave, Jia Meng, Carla D Pretto, Michael D Shields, Minh Trang Nguyen, Sean O Todd, Michael H Chi, Jason Hammonds, Stefanie A Krumm, Paul Spearman, Richard K Plemper, Kaori Sakamoto, R Stokes Peebles, Ultan F Power, Martin L Moore
Published 2016-05-01