Fragile X syndrome, the search for a targeted treatment

by Shimriet Zeidler, Rob Willemsen
Published 2019-07-01

Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously

by Shimriet Zeidler, Helen de Boer, Renate K. Hukema, Rob Willemsen
Published 2017-11-01

Editorial: Proceedings of the “Fourth International Conference of the FMR1 Premutation: Basic Mechanisms, Clinical Involvement and Therapy”

by Karen Usdin, Laia Rodriguez-Revenga, Rob Willemsen, Renate Hukema, Cecilia Giulivi, Cecilia Giulivi
Published 2021-04-01

Hair root FMRP expression for screening of fragile X full mutation females

by Lantip Rujito, Dwi Kustiani, Lies Anne Severijnen, Peter Hanzon, Sultana MH Faradz, Rob Willemsen
Published 2016-02-01

Hair root FMRP expression for screening of fragile X full mutation females

by Lantip Rujito, Dwi Kustiani, Lies Anne Severijnen, Peter Hanzon, Sultana MH Faradz, Rob Willemsen
Published 2011-04-01

Resultados preliminares del pesquisaje neonatal inmunohistoquímico para la detección del síndrome de frágil X Preliminary results of the immunohistochemical neonatal screening for...

by Roberto Lardoeyt Ferrer, Remigio Coto Rodeiro, Nereyda González Junco, Araceli Lantigua Cruz, C. Rob Willemsen
Published 2004-09-01

Genes and pathways differentially expressed in the brains of Fxr2 knockout mice

by Sebastiano Cavallaro, Sabrina Paratore, Francesco Fradale, Femke M.S. de Vrij, Rob Willemsen, Ben A. Oostra
Published 2008-12-01

Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish.

by Tianna Zhao, Herma Zondervan-van der Linde, Lies-Anne Severijnen, Ben A Oostra, Rob Willemsen, Vincenzo Bonifati
Published 2012-01-01

Generation and characterization of FMR1 knockout zebrafish.

by Marjo J den Broeder, Herma van der Linde, Judith R Brouwer, Ben A Oostra, Rob Willemsen, René F Ketting
Published 2009-11-01

Blood expression profiles of fragile X premutation carriers identify candidate genes involved in neurodegenerative and infertility phenotypes

by Elisabet Mateu-Huertas, Laia Rodriguez-Revenga, Maria Isabel Alvarez-Mora, Irene Madrigal, Rob Willemsen, Montserrat Milà, Eulàlia Martí, Xavier Estivill
Published 2014-05-01

Expression profiling suggests underexpression of the GABAA receptor subunit δ in the fragile X knockout mouse model

by Ilse Gantois, Jo Vandesompele, Frank Speleman, Edwin Reyniers, Rudi D'Hooge, Lies-Anne Severijnen, Rob Willemsen, Flora Tassone, R. Frank Kooy
Published 2006-02-01

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons

by Josien Levenga, Ronald A.M. Buijsen, Maria Rifé, Hervé Moine, David L. Nelson, Ben A. Oostra, Rob Willemsen, Femke M.S. de Vrij
Published 2009-08-01

Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

by Fréderike W. Riemslagh, Esmay C. van der Toorn, Rob F. M. Verhagen, Alex Maas, Laurens W. J. Bosman, Renate K. Hukema, Rob Willemsen
Published 2021-02-01

Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS

by Malgorzata Drozd, Sébastien Delhaye, Thomas Maurin, Sara Castagnola, Mauro Grossi, Frédéric Brau, Marielle Jarjat, Rob Willemsen, Maria Capovilla, Renate K. Hukema, Enzo Lalli, Barbara Bardoni
Published 2019-12-01

Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer.

by Diederick Duijvesz, Kristin E Burnum-Johnson, Marina A Gritsenko, A Marije Hoogland, Mirella S Vredenbregt-van den Berg, Rob Willemsen, Theo Luider, Ljiljana Paša-Tolić, Guido Jenster
Published 2013-01-01

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

by Femke M.S. de Vrij, Josien Levenga, Herma C. van der Linde, Sebastiaan K. Koekkoek, Chris I. De Zeeuw, David L. Nelson, Ben A. Oostra, Rob Willemsen
Published 2008-07-01

The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair

by Steven Bergink, Lies-Anne Severijnen, Nils Wijgers, Kaoru Sugasawa, Humaira Yousaf, Johan M. Kros, John van Swieten, Ben A. Oostra, Jan H. Hoeijmakers, Wim Vermeulen, Rob Willemsen
Published 2006-09-01

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

by Frederike W. Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne W. F. M. Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Jeroen Pasterkamp, John C. van Swieten, Rob Willemsen
Published 2019-03-01

IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

by Ya Gao, Maurice de Wit, Eduard A Struys, Herma C Z van der Linde, Gajja S Salomons, Martine L M Lamfers, Rob Willemsen, Peter A E Sillevis Smitt, Pim J French
Published 2018-01-01

Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15).

by Tianna Zhao, Esther De Graaff, Guido J Breedveld, Agnese Loda, Lies-Anne Severijnen, Cokkie H Wouters, Frans W Verheijen, Marieke C J Dekker, Pasquale Montagna, Rob Willemsen, Ben A Oostra, Vincenzo Bonifati
Published 2011-02-01