Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A

by Alexandra Sherman, Moanaro Biswas, Roland W. Herzog
Published 2017-11-01

Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia

by Sandeep R. P. Kumar, Xiaomei Wang, Nagavardhini Avuthu, Thais B. Bertolini, Cox Terhorst, Chittibabu Guda, Henry Daniell, Roland W. Herzog, Roland W. Herzog
Published 2020-05-01

Development of gene transfer for induction of antigen-specific tolerance

by Brandon K Sack, Roland W Herzog, Cox Terhorst, David M Markusic
Published 2014-01-01

Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice

by Roland W. Herzog, Veronica Kuteyeva, Rania Saboungi, Cox Terhorst, Moanaro Biswas
Published 2019-02-01

Gene Therapy With Regulatory T Cells: A Beneficial Alliance

by Moanaro Biswas, Sandeep R. P. Kumar, Cox Terhorst, Roland W. Herzog
Published 2018-03-01

A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells.

by Syandan Chakraborty, Nicolas Christoforou, Ali Fattahi, Roland W Herzog, Kam W Leong
Published 2013-01-01

An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells

by Brett Palaschak, Damien Marsic, Roland W. Herzog, Sergei Zolotukhin, David M. Markusic
Published 2017-06-01

Clinical development of gene therapy: results and lessons from recent successes

by Sandeep RP Kumar, David M Markusic, Moanaro Biswas, Katherine A High, Roland W Herzog
Published 2016-01-01

Targeted approaches to induce immune tolerance for Pompe disease therapy

by Phillip A Doerfler, Sushrusha Nayak, Manuela Corti, Laurence Morel, Roland W Herzog, Barry J Byrne
Published 2016-01-01

Gene Therapy Research at The Frontiers of Viral Immunology

by Brad E Hoffman, Hildegund CJ Ertl, Cox eTerhorst, Katherine A. High, Roland W. Herzog
Published 2012-05-01

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

by Irene Zolotukhin, David M Markusic, Brett Palaschak, Brad E Hoffman, Meera A Srikanthan, Roland W Herzog
Published 2016-01-01

Innate immune responses to AAV vectors

by Geoffrey L Rogers, Ashley T Martino, George V Aslanidi, Giridhara R Jayandharan, Arun eSrivastava, Roland W. Herzog
Published 2011-09-01

Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells

by Xiaomei Wang, Roland W. Herzog, Barry J. Byrne, Sandeep R.P. Kumar, Qi Zhou, Christian J. Buchholz, Moanaro Biswas
Published 2017-06-01

Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.

by Brandon K Sack, Sherin Merchant, David M Markusic, Amit C Nathwani, Andrew M Davidoff, Barry J Byrne, Roland W Herzog
Published 2012-01-01

Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer

by George Q Perrin, Irene Zolotukhin, Alexandra Sherman, Moanaro Biswas, Ype P de Jong, Cox Terhorst, Andrew M Davidoff, Roland W Herzog
Published 2016-01-01

The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease

by Ninghai Wang, Burcu Yigit, Cees E. van der Poel, Marta Cuenca, Michael C. Carroll, Roland W. Herzog, Pablo Engel, Cox Terhorst
Published 2019-04-01

Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.

by Ashley T Martino, Sushrusha Nayak, Brad E Hoffman, Mario Cooper, Gongxian Liao, David M Markusic, Barry J Byrne, Cox Terhorst, Roland W Herzog
Published 2009-08-01

Immune responses and hypercoagulation in ERT for Pompe disease are mutation and rhGAA dose dependent.

by Sushrusha Nayak, Phillip A Doerfler, Stacy L Porvasnik, Denise D Cloutier, Richie Khanna, Ken J Valenzano, Roland W Herzog, Barry J Byrne
Published 2014-01-01

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

by David M. Markusic, Timothy C. Nichols, Elizabeth P. Merricks, Brett Palaschak, Irene Zolotukhin, Damien Marsic, Sergei Zolotukhin, Arun Srivastava, Roland W. Herzog
Published 2017-05-01

Effect of CpG Depletion of Vector Genome on CD8+ T Cell Responses in AAV Gene Therapy

by Thais B. Bertolini, Jamie L. Shirley, Irene Zolotukhin, Xin Li, Tsuneyasu Kaisho, Tsuneyasu Kaisho, Weidong Xiao, Sandeep R. P. Kumar, Roland W. Herzog
Published 2021-05-01