CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.

by Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, Yufeng Xie, Andrew Freywald, Yulin Deng, Hong Ma, Jim Xiang
Published 2012-01-01

Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways.

by Channakeshava Sokke Umeshappa, Yufeng Xie, Shulin Xu, Roopa Hebbandi Nanjundappa, Andrew Freywald, Yulin Deng, Hong Ma, Jim Xiang
Published 2013-01-01

Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

by Channakeshava Sokke Umeshappa, Santiswarup Singha, Jesus Blanco, Kun Shao, Roopa Hebbandi Nanjundappa, Jun Yamanouchi, Albert Parés, Pau Serra, Yang Yang, Pere Santamaria
Published 2019-05-01