PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals

by Gabriel M. Cohn, Daniel F. Liefwalker, Ellen M. Langer, Ellen M. Langer, Rosalie C. Sears, Rosalie C. Sears, Rosalie C. Sears
Published 2020-04-01

Writing and erasing MYC ubiquitination and SUMOylation

by Yingxiao Chen, Xiao-Xin Sun, Rosalie C. Sears, Mu-Shui Dai
Published 2019-12-01

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy

by Xiao-Xin Sun, Yanping Li, Rosalie C. Sears, Mu-Shui Dai
Published 2021-06-01

Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer.

by Margaret P Chapman, Tyler Risom, Anil J Aswani, Ellen M Langer, Rosalie C Sears, Claire J Tomlin
Published 2019-03-01

Correction: Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer.

by Margaret P Chapman, Tyler Risom, Anil J Aswani, Ellen M Langer, Rosalie C Sears, Claire J Tomlin
Published 2019-10-01

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.

by Mahnaz Janghorban, Ellen M Langer, Xiaoyan Wang, Derek Zachman, Colin J Daniel, Jody Hooper, William H Fleming, Anupriya Agarwal, Rosalie C Sears
Published 2017-01-01

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

by Kevin Myant, Xi Qiao, Tuuli Halonen, Christophe Come, Anni Laine, Mahnaz Janghorban, Johanna I. Partanen, John Cassidy, Erinn-Lee Ogg, Patrizia Cammareri, Tiina Laiterä, Juha Okkeri, Juha Klefström, Rosalie C. Sears, Owen J. Sansom, Jukka Westermarck
Published 2015-08-01

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies

by Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan, Rosalie C. Sears
Published 2021-08-01

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

by Tyler Risom, Ellen M. Langer, Margaret P. Chapman, Juha Rantala, Andrew J. Fields, Christopher Boniface, Mariano J. Alvarez, Nicholas D. Kendsersky, Carl R. Pelz, Katherine Johnson-Camacho, Lacey E. Dobrolecki, Koei Chin, Anil J. Aswani, Nicholas J. Wang, Andrea Califano, Michael T. Lewis, Claire J. Tomlin, Paul T. Spellman, Andrew Adey, Joe W. Gray, Rosalie C. Sears
Published 2018-09-01

Loss of Ambra1 promotes melanoma growth and invasion

by Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi
Published 2021-05-01

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

by Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim, Daniel J. Murphy, Owen J. Sansom, Howard C. Crawford, Brett C. Sheppard, Rosalie C. Sears
Published 2017-11-01