Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.

by Christelle Cabrol, Malwina A Huzarska, Christopher Dinolfo, Maria C Rodriguez, Lael Reinstatler, Jake Ni, Li-An Yeh, Gregory D Cuny, Ross L Stein, Dennis J Selkoe, Malcolm A Leissring
Published 2009-01-01

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

by Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selkoe
Published 2010-05-01