Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate.

by Mariaelena Pistoni, Nicky Helsen, Jolien Vanhove, Ruben Boon, Zhuofei Xu, Laura Ordovas, Catherine M Verfaillie
Published 2017-01-01

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

by Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F. Orth, Catherine Verfaillie, Thomas G. P. Grünewald, Sarah-Maria Fendt
Published 2017-05-01

H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro

by Jolien Vanhove, Mariaelena Pistoni, Marc Welters, Kristel Eggermont, Veerle Vanslembrouck, Nicky Helsen, Ruben Boon, Mustapha Najimi, Etienne Sokal, Philippe Collas, J. Willem Voncken, Catherine M. Verfaillie
Published 2016-08-01

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways

by Javed K. Manesia, Zhuofei Xu, Dorien Broekaert, Ruben Boon, Alex van Vliet, Guy Eelen, Thomas Vanwelden, Steve Stegen, Nick Van Gastel, Alberto Pascual-Montano, Sarah-Maria Fendt, Geert Carmeliet, Peter Carmeliet, Satish Khurana, Catherine M. Verfaillie
Published 2015-11-01

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

by Jonathan De Smedt, Elise Anne van Os, Irene Talon, Sreya Ghosh, Burak Toprakhisar, Rodrigo Furtado Madeiro Da Costa, Samantha Zaunz, Marta Aguirre Vazquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie
Published 2021-01-01

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

by Juan Antonio García-León, Manoj Kumar, Ruben Boon, David Chau, Jennifer One, Esther Wolfs, Kristel Eggermont, Pieter Berckmans, Nilhan Gunhanlar, Femke de Vrij, Bas Lendemeijer, Benjamin Pavie, Nikky Corthout, Steven A. Kushner, José Carlos Dávila, Ivo Lambrichts, Wei-Shou Hu, Catherine M. Verfaillie
Published 2018-02-01

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

by Laura Ordovás, Ruben Boon, Mariaelena Pistoni, Yemiao Chen, Esther Wolfs, Wenting Guo, Rangarajan Sambathkumar, Sylwia Bobis-Wozowicz, Nicky Helsen, Jolien Vanhove, Pieter Berckmans, Qing Cai, Kim Vanuytsel, Kristel Eggermont, Veerle Vanslembrouck, Béla Z. Schmidt, Susanna Raitano, Ludo Van Den Bosch, Yaakov Nahmias, Toni Cathomen, Tom Struys, Catherine M. Verfaillie
Published 2015-11-01

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

by Laura Ordovás, Ruben Boon, Mariaelena Pistoni, Yemiao Chen, Esther Wolfs, Wenting Guo, Rangarajan Sambathkumar, Sylwia Bobis-Wozowicz, Nicky Helsen, Jolien Vanhove, Pieter Berckmans, Qing Cai, Kim Vanuytsel, Kristel Eggermont, Veerle Vanslembrouck, Béla Z. Schmidt, Susanna Raitano, Ludo Van Den Bosch, Yaakov Nahmias, Toni Cathomen, Tom Struys, Catherine M. Verfaillie
Published 2018-02-01

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

by Wenting Guo, Maximilian Naujock, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Ruben Boon, Laura Ordovás, Abdulsamie Patel, Marc Welters, Thomas Vanwelden, Natasja Geens, Tine Tricot, Veronick Benoy, Jolien Steyaert, Cynthia Lefebvre-Omar, Werend Boesmans, Matthew Jarpe, Jared Sterneckert, Florian Wegner, Susanne Petri, Delphine Bohl, Pieter Vanden Berghe, Wim Robberecht, Philip Van Damme, Catherine Verfaillie, Ludo Van Den Bosch
Published 2017-10-01

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

by Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie
Published 2020-03-01