What have we learned from gene expression profiles in Huntington's disease?

by Tamara Seredenina, Ruth Luthi-Carter
Published 2012-01-01

Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.

by Tamara Seredenina, Ozgun Gokce, Ruth Luthi-Carter
Published 2011-01-01

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation.

by Ozgun Gokce, Heike Runne, Alexandre Kuhn, Ruth Luthi-Carter
Published 2009-01-01

MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.

by Ana Jovicic, Julien Francisco Zaldivar Jolissaint, Roger Moser, Mariana de Fatima Silva Santos, Ruth Luthi-Carter
Published 2013-01-01

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

by Bin Tang, Tamara Seredenina, Giovanni Coppola, Alexandre Kuhn, Daniel H. Geschwind, Ruth Luthi-Carter, Elizabeth A. Thomas
Published 2011-06-01

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

by Delphine Charvin, Emmanuel Roze, Valérie Perrin, Carole Deyts, Sandrine Betuing, Christiane Pagès, Etienne Régulier, Ruth Luthi-Carter, Emmanuel Brouillet, Nicole Déglon, Jocelyne Caboche
Published 2008-01-01

An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.

by Abdelwahed Chtarto, Olivier Bockstael, Elias Gebara, Katia Vermoesen, Catherine Melas, Catherine Pythoud, Marc Levivier, Olivier De Witte, Ruth Luthi-Carter, Ralph Clinkers, Liliane Tenenbaum
Published 2013-01-01

HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.

by Michal Mielcarek, Tamara Seredenina, Matthew P Stokes, Georgina F Osborne, Christian Landles, Linda Inuabasi, Sophie A Franklin, Jeffrey C Silva, Ruth Luthi-Carter, Vahri Beaumont, Gillian P Bates
Published 2013-01-01

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.

by Karen N McFarland, Sudeshna Das, Ting Ting Sun, Dmitri Leyfer, Eva Xia, Gavin R Sangrey, Alexandre Kuhn, Ruth Luthi-Carter, Timothy W Clark, Ghazaleh Sadri-Vakili, Jang-Ho J Cha
Published 2012-01-01

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and...

by Ruth Luthi-Carter, Barbara L Apostol, Anthone W Dunah, Molly M DeJohn, Laurie A Farrell, Gillian P Bates, Anne B Young, David G Standaert, Leslie M Thompson, Jang-Ho J Cha
Published 2003-12-01

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

by Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Linda Inuabasi, Georgina F Osborne, Kristian Wadel, Chrystelle Touller, Rachel Butler, Janette Robertson, Sophie A Franklin, Donna L Smith, Larry Park, Paul A Marks, Erich E Wanker, Eric N Olson, Ruth Luthi-Carter, Herman van der Putten, Vahri Beaumont, Gillian P Bates
Published 2013-11-01