A Machine Learning Approach for High-Dimensional Time-to-Event Prediction With Application to Immunogenicity of Biotherapies in the ABIRISK Cohort

by Julianne Duhazé, Julianne Duhazé, Signe Hässler, Signe Hässler, Signe Hässler, Delphine Bachelet, Delphine Bachelet, Aude Gleizes, Aude Gleizes, Salima Hacein-Bey-Abina, Salima Hacein-Bey-Abina, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët, Philippe Broët
Published 2020-04-01

Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients

by Laura Magill, Marsilio Adriani, Véronique Berthou, Keguan Chen, Aude Gleizes, Aude Gleizes, Salima Hacein-Bey-Abina, Salima Hacein-Bey-Abina, Agnes Hincelin-Mery, Xavier Mariette, Marc Pallardy, Sebastian Spindeldreher, Natacha Szely, David A. Isenberg, Jessica J. Manson, Elizabeth C. Jury, Claudia Mauri
Published 2018-12-01

Regulatory T Cells Increase After rh-MOG Stimulation in Non-Relapsing but Decrease in Relapsing MOG Antibody-Associated Disease at Onset in Children

by Philippe Horellou, Aliénor de Chalus, Aliénor de Chalus, Laetitia Giorgi, Laetitia Giorgi, Carole Leroy, Carole Leroy, Pascale Chrétien, Pascale Chrétien, Salima Hacein-Bey-Abina, Salima Hacein-Bey-Abina, Christine Bourgeois, Xavier Mariette, Xavier Mariette, Ché Serguera, Roger Le Grand, Kumaran Deiva, Kumaran Deiva, Kumaran Deiva
Published 2021-06-01

Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach

by Julianne Duhazé, Miguel Caubet, Signe Hässler, Delphine Bachelet, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Aude Gleizes, Salima Hacein-Bey-Abina, Xavier Mariette, Marc Pallardy, Philippe Broët, on behalf of the ABIRISK Consortium
Published 2020-03-01

Biosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene Therapy of Artemis-SCID

by Sabine Charrier, Chantal Lagresle-Peyrou, Valentina Poletti, Michael Rothe, Grégory Cédrone, Bernard Gjata, Fulvio Mavilio, Alain Fischer, Axel Schambach, Jean-Pierre de Villartay, Marina Cavazzana, Salima Hacein-Bey-Abina, Anne Galy
Published 2019-12-01

Real-time definition of non-randomness in the distribution of genomic events.

by Ulrich Abel, Annette Deichmann, Cynthia Bartholomae, Kerstin Schwarzwaelder, Hanno Glimm, Steven Howe, Adrian Thrasher, Alexandrine Garrigue, Salima Hacein-Bey-Abina, Marina Cavazzana-Calvo, Alain Fischer, Dirk Jaeger, Christof von Kalle, Manfred Schmidt
Published 2007-01-01

INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions

by Charles C. Berry, Christopher Nobles, Emmanuelle Six, Yinghua Wu, Nirav Malani, Eric Sherman, Anatoly Dryga, John K. Everett, Frances Male, Aubrey Bailey, Kyle Bittinger, Mary J. Drake, Laure Caccavelli, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Published 2017-03-01

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

by Eric Sherman, Christopher Nobles, Charles C. Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K. Everett, Laure Caccavelli, Mary J. Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Published 2017-03-01

T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

by Erik L. Clarke, A. Jesse Connell, Emmanuelle Six, Nadia A. Kadry, Arwa A. Abbas, Young Hwang, John K. Everett, Casey E. Hofstaedter, Rebecca Marsh, Myriam Armant, Judith Kelsen, Luigi D. Notarangelo, Ronald G. Collman, Salima Hacein-Bey-Abina, Donald B. Kohn, Marina Cavazzana, Alain Fischer, David A. Williams, Sung-Yun Pai, Frederic D. Bushman
Published 2018-09-01

Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium.

by Signe Hässler, Delphine Bachelet, Julianne Duhaze, Natacha Szely, Aude Gleizes, Salima Hacein-Bey Abina, Orhan Aktas, Michael Auer, Jerôme Avouac, Mary Birchler, Yoram Bouhnik, Olivier Brocq, Dorothea Buck-Martin, Guillaume Cadiot, Franck Carbonnel, Yehuda Chowers, Manuel Comabella, Tobias Derfuss, Niek De Vries, Naoimh Donnellan, Abiba Doukani, Michael Guger, Hans-Peter Hartung, Eva Kubala Havrdova, Bernhard Hemmer, Tom Huizinga, Kathleen Ingenhoven, Poul Erik Hyldgaard-Jensen, Elizabeth C Jury, Michael Khalil, Bernd Kieseier, Anna Laurén, Raija Lindberg, Amy Loercher, Enrico Maggi, Jessica Manson, Claudia Mauri, Badreddine Mohand Oumoussa, Xavier Montalban, Maria Nachury, Petra Nytrova, Christophe Richez, Malin Ryner, Finn Sellebjerg, Claudia Sievers, Dan Sikkema, Martin Soubrier, Sophie Tourdot, Caroline Trang, Alessandra Vultaggio, Clemens Warnke, Sebastian Spindeldreher, Pierre Dönnes, Timothy P Hickling, Agnès Hincelin Mery, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët, ABIRISK consortium
Published 2020-10-01