Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo.

by Shariya Terrell, Samuel H Speck
Published 2017-08-01

Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells.

by Udaya S Rangaswamy, Samuel H Speck
Published 2014-01-01

Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivo.

by Christopher M Collins, Samuel H Speck
Published 2012-01-01

A tissue culture model of murine gammaherpesvirus replication reveals roles for the viral cyclin in both virus replication and egress from infected cells.

by Francine M Scott, Samuel H Speck
Published 2014-01-01

Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency.

by Christopher M Collins, Samuel H Speck
Published 2015-04-01

Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help.

by Christopher M Collins, Samuel H Speck
Published 2014-05-01

Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection.

by Kathleen S Gray, Christopher M Collins, Samuel H Speck
Published 2012-01-01

Tyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivo.

by Udaya S Rangaswamy, Brigid M O'Flaherty, Samuel H Speck
Published 2014-01-01

The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation.

by Andrea M Siegel, Jeremy H Herskowitz, Samuel H Speck
Published 2008-04-01

Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.

by Laurie T Krug, Janice M Moser, Shelley M Dickerson, Samuel H Speck
Published 2007-01-01

The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cells.

by Brigid M O'Flaherty, Tanushree Soni, Brian S Wakeman, Samuel H Speck
Published 2014-08-01

Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses.

by Kelly B McClellan, Shivaprakash Gangappa, Samuel H Speck, Herbert W Virgin
Published 2006-06-01

Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.

by Clinton R Paden, J Craig Forrest, Scott A Tibbetts, Samuel H Speck
Published 2012-09-01

Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes.

by Xiaozhen Liang, Christopher M Collins, Justin B Mendel, Neal N Iwakoshi, Samuel H Speck
Published 2009-11-01

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.

by Christopher M Collins, Christopher D Scharer, Thomas J Murphy, Jeremy M Boss, Samuel H Speck
Published 2020-04-01

Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen.

by Xiaozhen Liang, Clinton R Paden, Francine M Morales, Ryan P Powers, Joshy Jacob, Samuel H Speck
Published 2011-09-01

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity.

by Caline G Matar, Neil R Anthony, Brigid M O'Flaherty, Nathan T Jacobs, Lalita Priyamvada, Christian R Engwerda, Samuel H Speck, Tracey J Lamb
Published 2015-05-01

CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.

by Brigid M O'Flaherty, Caline G Matar, Brian S Wakeman, AnaPatricia Garcia, Carol A Wilke, Cynthia L Courtney, Bethany B Moore, Samuel H Speck
Published 2015-01-01

A surface groove essential for viral Bcl-2 function during chronic infection in vivo.

by Joy Loh, Qiulong Huang, Andrew M Petros, David Nettesheim, Linda F van Dyk, Lucia Labrada, Samuel H Speck, Beth Levine, Edward T Olejniczak, Herbert W Virgin
Published 2005-09-01

Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation.

by Shuai Liu, Zhangmengxue Lei, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H Speck, Xiaozhen Liang
Published 2020-07-01