Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge.

by Hugh C Welles, Madeleine F Jennewein, Rosemarie D Mason, Sandeep Narpala, Lingshu Wang, Cheng Cheng, Yi Zhang, John-Paul Todd, Jeffrey D Lifson, Alejandro B Balazs, Galit Alter, Adrian B McDermott, John R Mascola, Mario Roederer
Published 2018-12-01

Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection.

by Kristin L Boswell, Robert Paris, Eli Boritz, David Ambrozak, Takuya Yamamoto, Sam Darko, Kaska Wloka, Adam Wheatley, Sandeep Narpala, Adrian McDermott, Mario Roederer, Richard Haubrich, Mark Connors, Julie Ake, Daniel C Douek, Jerome Kim, Constantinos Petrovas, Richard A Koup
Published 2014-01-01

A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2

by Abdelilah Majdoubi, Christina Michalski, Sarah E. O’Connell, Sarah Dada, Sandeep Narpala, Jean Gelinas, Disha Mehta, Claire Cheung, Dirk F.H. Winkler, Manjula Basappa, Aaron C. Liu, Matthias Görges, Vilte E. Barakauskas, Mike Irvine, Jennifer Mehalko, Dominic Esposito, Inna Sekirov, Agatha N. Jassem, David M. Goldfarb, Steven Pelech, Daniel C. Douek, Adrian B. McDermott, Pascal M. Lavoie
Published 2021-04-01

Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

by Leila Eslamizar, Constantinos Petrovas, David J. Leggat, Kathryn Furr, Michelle L. Lifton, Gail Levine, Steven Ma, Christopher Fletez-Brant, Wesley Hoyland, Madhu Prabhakaran, Sandeep Narpala, Kristin Boswell, Takuya Yamamoto, Hua-Xin Liao, David Pickup, Elizabeth Ramsburg, Laura Sutherland, Adrian McDermott, Mario Roederer, David Montefiori, Richard A. Koup, Barton F. Haynes, Norman L. Letvin, Sampa Santra
Published 2021-01-01

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

by M. Gordon Joyce, Ivelin S. Georgiev, Yongping Yang, Aliaksandr Druz, Hui Geng, Gwo-Yu Chuang, Young Do Kwon, Marie Pancera, Reda Rawi, Mallika Sastry, Guillaume B.E. Stewart-Jones, Angela Zheng, Tongqing Zhou, Misook Choe, Joseph G. Van Galen, Rita E. Chen, Christopher R. Lees, Sandeep Narpala, Michael Chambers, Yaroslav Tsybovsky, Ulrich Baxa, Adrian B. McDermott, John R. Mascola, Peter D. Kwong
Published 2017-12-01

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

by Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood, VRC 606 Study Team
Published 2018-01-01

Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base

by Angela R. Corrigan, Hongying Duan, Cheng Cheng, Christopher A. Gonelli, Li Ou, Kai Xu, Megan E. DeMouth, Hui Geng, Sandeep Narpala, Sarah O’Connell, Baoshan Zhang, Tongqing Zhou, Manjula Basappa, Jeffrey C. Boyington, Steven J. Chen, Sijy O’Dell, Amarendra Pegu, Tyler Stephens, Yaroslav Tsybovsky, Jelle van Schooten, John P. Todd, Shuishu Wang, Nicole A. Doria-Rose, Kathryn E. Foulds, Richard A. Koup, Adrian B. McDermott, Marit J. van Gils, Peter D. Kwong, John R. Mascola
Published 2021-04-01

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

by Tongqing Zhou, Nicole A. Doria-Rose, Cheng Cheng, Guillaume B.E. Stewart-Jones, Gwo-Yu Chuang, Michael Chambers, Aliaksandr Druz, Hui Geng, Krisha McKee, Young Do Kwon, Sijy O’Dell, Mallika Sastry, Stephen D. Schmidt, Kai Xu, Lei Chen, Rita E. Chen, Mark K. Louder, Marie Pancera, Timothy G. Wanninger, Baoshan Zhang, Anqi Zheng, S. Katie Farney, Kathryn E. Foulds, Ivelin S. Georgiev, M. Gordon Joyce, Thomas Lemmin, Sandeep Narpala, Reda Rawi, Cinque Soto, John-Paul Todd, Chen-Hsiang Shen, Yaroslav Tsybovsky, Yongping Yang, Peng Zhao, Barton F. Haynes, Leonidas Stamatatos, Michael Tiemeyer, Lance Wells, Diana G. Scorpio, Lawrence Shapiro, Adrian B. McDermott, John R. Mascola, Peter D. Kwong
Published 2017-04-01